Figure 1
From: Bone loss: Therapeutic approaches for preventing bone loss in inflammatory arthritis
Osteoclastogenesis. Osteoclasts are derived from bone marrow cells, and RANKL-OPG derived from bone or synovium has a significant effect in their differentiation, activation, and survival. CTR = calcitonin receptor; M-CSF = macrophage colony-stimulating factor; OB = osteoblast; OC = osteoclast; OPG = osteoprotegerin; RANKL = receptor activator of nuclear factor-κB ligand; TRAP = tartrate-resistant acid phosphatase.