Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitroeffects on cartilage metabolism and intra-articular levels after injection

Table 2 Clinical scores and serum cytokine levels in patients with sufficient and with non-sufficient SF for analysis

	KOOS score	KSCRS score	Baseline serum cytokine levels
			IL-1	IL-4	IL-6	IL-10	IL-13	TNFα	IFNγ	OSM	OPG	IL-1ra
SF available and analysed (14 patients)	46 (10)	79 (19)	0.2 (0.7)	0.0 (0.0)	8.5 (28)	1.5 (2.7)	0.0 (0.1)	0.0 (0.2)	2.2 (2.2)	13 (27)	376 (128)	180 (137)
No SF available (8 patients)	51 (15)	75 (15)	0.2 (0.6)	0.0 (0.0)	0.1 (0.2)	0.1 (0.2)	0.1 (0.2)	14 (29)	16 (44)	14 (29)	371 (229)	276 (288)

Pre-treatment clinical OA and baseline serum characteristics (mean +/- SD) of patients whose synovial fluid were analysed, were similar to those of patients whose synovial fluid were not analysed due to insufficient amounts of SF in the knee at time of aspiration.
KOOS, Knee and Osteoarthritis Outcome Score; KSCRS, Knee Society Clinical Rating Scale; SF, synovial fluid; OA, osteoarthritis; IL-4, interleukin-4; IL-6, interleukin-6; IL-10, interleukin-10; IL-13, interleukin-13; IFN-γ, interferon gamma; OSM, oncostatin M; TNF-α, tumor necrosis factor alpha; OPG, osteoprotegerin; IL-1ra, interleukin-1 receptor antagonist.

ISSN: 1478-6362