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Table 3 Association analysis of the KIAA1109-TENR-IL2-IL21 SNPs rs17388568 and rs907715 with RA in three European Caucasian case-control sample sets

From: Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844with rheumatoid arthritis at a genome-wide level of significance

  Genotype, no. (frequency)1,2 Minor allele, no. (frequency) OR [95% CI] P
Sample Set 1/1 1/24 2/2    
rs17388568       
WTCCC [22]       
Case 938 (0.505) 773 (0.416) 145 (0.078) 1,063 (0.286) 1.14 (1.04 to 1.25) 0.005
Control 1,610 (0.549) 1,119 (0.381) 204 (0.070) 1,527 (0.260)   
Barton [12]       
Case 2,057 (0.528) 1,530 (0.393) 308 (0.079) 2,146 (0.275) 0.97 (0.91 to 1.05) 0.47
Control 1,797 (0.516) 1,415 (0.406) 271 (0.077) 1,957 (0.281)   
Australasian       
Case 453 (0.543) 305 (0.366) 76 (0.091) 457 (0.274) 1.03 (0.90 to 1.19) 0.654
Control 584 (0.584) 461 (0.415) 67 (0.060) 595 (0.268)   
rs907715       
WTCCC [22]       
Case 835 (0.450) 822 (0.443) 199 (0.107) 1,220 (0.329) 0.92 (0.84 to 1.00) 0.055
Control 1,251 (0.427) 1,324 (0.451) 358 (0.122) 2,040 (0.349)   
Australasian       
Case 365 (0.438) 374 (0.449) 94 (0.113) 562 (0.337) 0.98 (0.86 to 1.12) 0.687
Control 468 (0.421) 524 (0.471) 120 (0.108) 764 (0.344)   
  1. (1) There was one significant departure from Hardy-Weinberg equilibrium, P = 0.02 in Australasian cases
  2. (2) Genotype data were imputed in the WTCCC sample set for rs907715, and directly genotyped in all others