Table 3 Association analysis of the KIAA1109-TENR-IL2-IL21 SNPs rs17388568 and rs907715 with RA in three European Caucasian case-control sample sets
| Â | Genotype, no. (frequency)1,2 | Minor allele, no. (frequency) | OR [95% CI] | P | ||
|---|---|---|---|---|---|---|
Sample Set | 1/1 | 1/24 | 2/2 | Â | Â | Â |
rs17388568 | Â | Â | Â | Â | Â | Â |
WTCCC [22] | Â | Â | Â | Â | Â | Â |
Case | 938 (0.505) | 773 (0.416) | 145 (0.078) | 1,063 (0.286) | 1.14 (1.04 to 1.25) | 0.005 |
Control | 1,610 (0.549) | 1,119 (0.381) | 204 (0.070) | 1,527 (0.260) | Â | Â |
Barton [12] | Â | Â | Â | Â | Â | Â |
Case | 2,057 (0.528) | 1,530 (0.393) | 308 (0.079) | 2,146 (0.275) | 0.97 (0.91 to 1.05) | 0.47 |
Control | 1,797 (0.516) | 1,415 (0.406) | 271 (0.077) | 1,957 (0.281) | Â | Â |
Australasian | Â | Â | Â | Â | Â | Â |
Case | 453 (0.543) | 305 (0.366) | 76 (0.091) | 457 (0.274) | 1.03 (0.90 to 1.19) | 0.654 |
Control | 584 (0.584) | 461 (0.415) | 67 (0.060) | 595 (0.268) | Â | Â |
rs907715 | Â | Â | Â | Â | Â | Â |
WTCCC [22] | Â | Â | Â | Â | Â | Â |
Case | 835 (0.450) | 822 (0.443) | 199 (0.107) | 1,220 (0.329) | 0.92 (0.84 to 1.00) | 0.055 |
Control | 1,251 (0.427) | 1,324 (0.451) | 358 (0.122) | 2,040 (0.349) | Â | Â |
Australasian | Â | Â | Â | Â | Â | Â |
Case | 365 (0.438) | 374 (0.449) | 94 (0.113) | 562 (0.337) | 0.98 (0.86 to 1.12) | 0.687 |
Control | 468 (0.421) | 524 (0.471) | 120 (0.108) | 764 (0.344) | Â | Â |