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Table 1 Knee joint histology, tibial cartilage material property, and trabecular bone osteoarthritis outcomes

From: Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice

Parameter Control LG HG Diet (Pvalue) Diet × percentage body fat (Pvalue)
Knee modified Mankin score 18.2 ± 1.5 15.8 ± 2.5 25.1 ± 1.5* 0.17 0.003
Cartilage degeneration 4.4 ± 0.7 5.1 ± 0.9 6.7 ± 0.9 0.11 0.47
Safranin-O loss 7.7 ± 1.0 3.8 ± 0.3* 11.7 ± 0.8*# 0.66 <0.001
Tidemark duplication 0.22 ± 0.11 0.16 ± 0.10 0.13 ± 0.13 0.60 0.29
Chondrocyte cloning 0.67 ± 0.22 0.42 ± 0.16 1.1 ± 0.3 0.70 0.14
Hypertrophic chondrocytes 1.8 ± 0.3 1.3 ± 0.7 2.1 ± 0.4 0.88 0.18
Fibrocartilage 0.04 ± 0.04 0.33 ± 0.33 0 ± 0 0.48 0.34
Relative subchondral bone thickness 3.4 ± 0.3 4.7 ± 0.5 3.5 ± 0.7 0.26 0.31
Aggregate modulus (HA) 1.49 ± 0.18 2.18 ± 0.03 1.74 ± 0.20 0.003 0.10
Permeability (× 10-16, m4/N-s) 2.38 ± 0.67 1.90 ± 0.32 1.80 ± 0.60 0.48 0.77
Relative tibial epiphysis trabecular bone volume 0.43 ± 0.02 0.51 ± 0.07 0.40 ± 0.03 0.56 0.72
  1. Statistical differences among control, low gainer (LG), and high gainer (HG) values were determined with a hierarchical analysis of variance. Overall diet and diet × percentage body fat effects were analyzed by analysis of covariance. *P < 0.05 compared with control values. #P < 0.05 for HG versus LG values. P values less than 0.05 shown in bold.