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Table 6 Functional enrichment in gene categories in patients with skin ulcers compared to those without ulcers

From: Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion

Biological process

Number of probe sets

P-value

Immune response

210

0.0000000009

Defense response

221

0.0000000145

Response to wounding

109

0.0000012730

Signal transducer activity

472

0.0000206037

Response to stress

236

0.0000215677

Regulation of cell proliferation

89

0.0000403309

Positive regulation of nitric oxide biosynthesis

8

0.0001150065

Positive regulation of biosynthesis

16

0.0001813324

Receptor activity

290

0.0003570920

Cell activation

36

0.0005153290

Cell proliferation

137

0.001020579

Positive regulation of innate immune response

3

0.001302911

Regulation of immune response

27

0.001521656

Inflammatory response

47

0.002011958

Positive regulation of immune response

20

0.002900865

Cell adhesion

136

0.006908177

Cytokine activity

47

0.017808983