Figure 1From: Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritisTotal nuclear histone deacetylase (HDAC) and histone deacetylase (HAT) activity in synovial tissues. (a) Nuclear HDAC activity in synovial tissues that were obtained from rheumatoid arthritis (RA, n = 14) patients was significantly increased compared to that from normal controls (n = 3) and osteoarthritis (OA, n = 12). In the box (interquartile range, IQR) and whisker (maximum and minimum) plots, the horizontal line inside the box denoted median and the filled circles denote outliers outside IQR ± 1.5 × IQR. * = P < 0.05 versus normal controls, ** = P < 0.05 versus OA. (b) Nuclear HAT activity was measured in synovial tissues that were obtained from normal controls (n = 3), OA (n = 5) and RA patients (n = 5). There was no significant difference between normal controls, OA and RA synovial tissues.Back to article page