Figure 6

Pathways and networks related to chondrocyte proteins identified by proteomics as altered by GS and/or CS. Pathway Studio software was used to map the identified proteins into characterized human pathways and networks that associate proteins based on known protein-protein interactions, mRNA expression studies and other previously described biochemical interactions. Abbreviations are shown as in Table 1. Most of the proteins modulated by GS belong to the unfolded protein response (UPR) system, while CS seems to affect mainly energy production (glycolysis) and metabolic pathways.