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Table 3 Effect of monosodium urate on macrophage DNA synthesis

From: Inflammatory microcrystals induce murine macrophage survival and DNA synthesis

Addition [3H]TdR incorporation (cpm × 10-4)
None   1.6 ± 0.1
MSU 13.5 ± 0.5
BCP 24.3 ± 0.3
  1. BMMs from which CSF-1 had just been removed were cultured in RPMI/10%FBS, in the absence or presence of monosodium urate (MSU) (500 μg/ml) or BCP (500 μg/ml). After one day, cells were pulsed with [3H]TdR for a further two days. Data are mean values ± SEM from triplicate cultures and are from a representative experiment that was repeated twice.