Figure 4

Histological effects of liposomal DxM-P in adjuvant arthritis (Day 21; Experiment 2/3). Inflammation and destruction score (a) and images of HE-stained joints sections from healthy controls (b) or arthritic rats after treatment with PBS (c), PBS-liposomes (d), free DxM-P (e), or liposomal DxM-P (f) (for details see Figure 1). + P ≤ 0.05, ++ P ≤ 0.01 vs. AA/PBS; # P ≤ 0.05, ## P ≤ 0.01 vs. AA/PBS-liposomes; all Mann Whitney U-test.