Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

Table 1 Associations between structural, remodelling and molecular parameters at subchondral bone, and cartilage damage score

	B.Ar/T.Ar%	Sb. Th	FD	Ip	ALP	MMP9	OPG/RANKL	MANKIN
B.Ar/T.Ar%	1.000
Sb. Th	0.381*	1.000
FD	-0.861**	-0.450*	1.000
Ip	0.963**	0.347	-0.868**	1.000
ALP	0.814**	0.453	-0.754**	0.718**	1.000
MMP9	-0.115	-0.195	0.262	-0.094	-0.311	1.000
OPG/RANKL	-0.280	-0.120	0.340	-0.247	-0.054	0.500*	1.000
MANKIN	-0.627**	-0.626**	0.672**	-0.598**	-0.788**	0.460	0.341	1.000

* Correlation is significant at the 0.05 level (2-tailed).
** Correlation is significant at the 0.001 level (2-tailed).
The correlation coefficients represented in this table are obtained comparing the healthy, OA, OP and OPOA groups by Spearman bivariate analysis.
B.Ar/T.Ar%, bone area fraction; FD, fractal dimension; Ip, polar moment of inertia; MANKIN, cartilage histopathological Mankin grading scorel; MMP9, metalloproteinase 9; OA, osteoarthritis; OP, osteoporosis; OPG/RANKL ratio, osteoprotegerin/receptor activator of nuclear factor-κB ratio; Sb.Th, subchondral plate thickness.

ISSN: 1478-6362