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Table 1 Associations between structural, remodelling and molecular parameters at subchondral bone, and cartilage damage score

From: Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

  B.Ar/T.Ar% Sb. Th FD Ip ALP MMP9 OPG/RANKL MANKIN
B.Ar/T.Ar% 1.000        
Sb. Th 0.381* 1.000       
FD -0.861** -0.450* 1.000      
Ip 0.963** 0.347 -0.868** 1.000     
ALP 0.814** 0.453 -0.754** 0.718** 1.000    
MMP9 -0.115 -0.195 0.262 -0.094 -0.311 1.000   
OPG/RANKL -0.280 -0.120 0.340 -0.247 -0.054 0.500* 1.000  
MANKIN -0.627** -0.626** 0.672** -0.598** -0.788** 0.460 0.341 1.000
  1. * Correlation is significant at the 0.05 level (2-tailed).
  2. ** Correlation is significant at the 0.001 level (2-tailed).
  3. The correlation coefficients represented in this table are obtained comparing the healthy, OA, OP and OPOA groups by Spearman bivariate analysis.
  4. B.Ar/T.Ar%, bone area fraction; FD, fractal dimension; Ip, polar moment of inertia; MANKIN, cartilage histopathological Mankin grading scorel; MMP9, metalloproteinase 9; OA, osteoarthritis; OP, osteoporosis; OPG/RANKL ratio, osteoprotegerin/receptor activator of nuclear factor-κB ratio; Sb.Th, subchondral plate thickness.