Table 1 Baseline characteristics of the study cohort 12 months prior to the index date
|
RA patients (n= 47,034) |
Non-RA patients§ (n= 235,170) | |
|---|---|---|
| Demographic | ||
| Age, years | 55 (46-64) | 55 (46-64) |
| Sex, female | 34,169 (73) | 170,845 (73) |
| Osteoporosis-related | ||
| Osteoporosis diagnosis | 8,385 (18) | 16,724 (7) |
| Osteoporosis medication | 5,634 (12) | 14,067 (6) |
| Prior fracture | 413 (0.9) | 1,322 (0.6) |
| Bone mineral density test | 5,802 (12) | 13,307 (6) |
| Parkinson's disease | 177 (0.4) | 718 (0.3) |
| Alzheimer's disease | 156 (0.3) | 752 (0.3) |
| Prior fall | 609 (1) | 2351 (1) |
| At least one comorbidity | 39,259 (83) | 53,299 (23) |
| Comorbidity index * | 1 (1-2) | 0 (0-0) |
| CIRAS score | 5.2 (3.7-6.9) | 3.6 (2.9-4.3) |
| Medication use | ||
| Oral glucocorticoids | 18,222 (39) | 15,342 (7) |
| Anticonvulsants | 3,703 (8) | 7,795 (3) |
| Benzodiazepines | 8,362 (18) | 25,754 (11) |
| SSRIs | 7,289 (16) | 22,920 (10) |
| Beta-blockers | 6,520 (14) | 25,166 (11) |
| Proton pump inhibitors | 9,415 (20) | 19,859 (8) |
| Opioids | 22,049 (47) | 54,204 (23) |
| Health care utilization | ||
| Number of physician visits | 8 (5-14) | 2 (0-6) |
| Hospitalizations | 8,894 (19) | 25,131(11) |
| Number of all prescription drugs | 8 (4-13) | 3 (0-7) |