A multiparameter approach to monitor disease activity in collagen-induced arthritis

Table 4 Best-fit models for cartilage and bone destruction predicted by both scoring methods and serum markers

Dependent variable	Best-fit model	Adjusted R²	Significance
Cartilage destruction	Larsen score	0.530	< 0.001
	Larsen score + micro-CT calcaneus score	0.664	< 0.001
	Larsen score + micro-CT calcaneus score + clinical score	0.700	< 0.001
Bone destruction	Micro-CT calcaneus score	0.602	< 0.001
	Micro-CT calcaneus score + Larsen score	0.711	< 0.001
	Micro-CT calcaneus score + Larsen score + COMP	0.731	< 0.001

Best-fit models for cartilage and bone destruction in the paw as proposed by linear regression analysis with all scoring methods and serum markers and treatment group as independent variables. COMP, cartilage oligomeric matrix protein.

ISSN: 1478-6362