Arthrotropism of N -(2-hydroxypropyl)methacrylamide copolymer conjugates. (a) Maximum intensity projection images (black and white) of a representative adjuvant-induced arthritis (AA) rat right-hind limb from different angles (anterior, lateral and posterior), superimposed with a tissue transfer constant of P-DOTA-Gd3+ (K
) map (color). Inserted color bar represents the color code for K
values in the map from 0 to 0.005/min. (b) Biodistribution of 125I-labeled acid-labile N-(2-hydroxypropyl)methacrylamide copolymer-dexamethasone conjugate (P-Dex) in healthy rats (open bars) and in AIA rats (solid bars) at 24 hours post administration.