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Table 2 Association study of TNIP1 rs7708392 with SLE in a Japanese population
| Genotype | Allele | Allelic association | Recessive model* | |||||
|---|---|---|---|---|---|---|---|---|
| C/C | C/G | G/G | C | P | OR (95%CI) | P | OR (95%CI) | |
| All SLE (n = 364) | 216 (59.3) | 125 (34.3) | 23 (6.3) | 557 (76.5) | 0.0022 | 1.40 (1.13-1.74) | 0.0023 | 1.52 (1.16-2.00) |
| SLE subsets | ||||||||
| Renal disorder + (n = 203) | 126 (62.1) | 68 (33.5) | 9 (4.4) | 320 (78.8) | 0.00065 | 1.60 (1.22-2.10) | 0.0015 | 1.71 (1.23-2.38) |
| Neurologic disorder + (n = 53) | 28 (52.8) | 21 (39.6) | 4 (7.5) | 77 (72.6) | 0.55 | 1.14 (0.73-1.79) | 0.59 | 1.17 (0.66-2.05) |
| Serositis + (n = 55) | 33 (60.0) | 18 (32.7) | 4 (7.3) | 84 (76.4) | 0.16 | 1.39 (0.88-2.20) | 0.12 | 1.57 (0.89-2.75) |
| Anti-dsDNA Ab + (n = 280) | 169 (60.4) | 93 (33.2) | 18 (6.4) | 431 (77.0) | 0.0026 | 1.44 (1.14-1.83) | 0.0021 | 1.59 (1.18-2.13) |
| Anti-Sm Ab + (n = 67) | 37 (55.2) | 26 (38.8) | 4 (6.0) | 100 (74.6) | 0.26 | 1.27 (0.84-1.91) | 0.33 | 1.29 (0.77-2.15) |
| Onset <20 yr (n = 86) | 46 (53.5) | 34 (39.5) | 6 (7.0) | 126 (73.3) | 0.37 | 1.18 (0.82-1.70) | 0.43 | 1.20 (0.76-1.90) |
| Healthy controls (n = 513) | 251 (48.9) | 215 (41.9) | 47 (9.2) | 717 (69.9) | reference | reference | ||
