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Table 2 Association study of TNIP1 rs7708392 with SLE in a Japanese population

From: Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study

  Genotype Allele Allelic association Recessive model*
  C/C C/G G/G C P OR (95%CI) P OR (95%CI)
All SLE (n = 364) 216 (59.3) 125 (34.3) 23 (6.3) 557 (76.5) 0.0022 1.40 (1.13-1.74) 0.0023 1.52 (1.16-2.00)
SLE subsets         
   Renal disorder + (n = 203) 126 (62.1) 68 (33.5) 9 (4.4) 320 (78.8) 0.00065 1.60 (1.22-2.10) 0.0015 1.71 (1.23-2.38)
   Neurologic disorder + (n = 53) 28 (52.8) 21 (39.6) 4 (7.5) 77 (72.6) 0.55 1.14 (0.73-1.79) 0.59 1.17 (0.66-2.05)
   Serositis + (n = 55) 33 (60.0) 18 (32.7) 4 (7.3) 84 (76.4) 0.16 1.39 (0.88-2.20) 0.12 1.57 (0.89-2.75)
   Anti-dsDNA Ab + (n = 280) 169 (60.4) 93 (33.2) 18 (6.4) 431 (77.0) 0.0026 1.44 (1.14-1.83) 0.0021 1.59 (1.18-2.13)
   Anti-Sm Ab + (n = 67) 37 (55.2) 26 (38.8) 4 (6.0) 100 (74.6) 0.26 1.27 (0.84-1.91) 0.33 1.29 (0.77-2.15)
   Onset <20 yr (n = 86) 46 (53.5) 34 (39.5) 6 (7.0) 126 (73.3) 0.37 1.18 (0.82-1.70) 0.43 1.20 (0.76-1.90)
Healthy controls (n = 513) 251 (48.9) 215 (41.9) 47 (9.2) 717 (69.9)   reference   reference
  1. OR: odds ratio, 95% CI: confidence interval. Genotype and allele frequencies are shown in parentheses (%).
  2. Association was tested by χ2 analysis using 2 × 2 contingency tables. All SLE group as well as each SLE subset was compared with healthy controls.
  3. *Association was tested under the recessive model for rs7708392C allele.