| |
Genotype
|
Allele
|
Allelic association
|
Recessive model*
|
|---|
| |
C/C
|
C/G
|
G/G
|
C
|
P
|
OR (95%CI)
|
P
|
OR (95%CI)
|
|---|
|
All SLE (n = 364)
|
216 (59.3)
|
125 (34.3)
|
23 (6.3)
|
557 (76.5)
|
0.0022
|
1.40 (1.13-1.74)
|
0.0023
|
1.52 (1.16-2.00)
|
|
SLE subsets
| | | | | | | | |
|
Renal disorder + (n = 203)
|
126 (62.1)
|
68 (33.5)
|
9 (4.4)
|
320 (78.8)
|
0.00065
|
1.60 (1.22-2.10)
|
0.0015
|
1.71 (1.23-2.38)
|
|
Neurologic disorder + (n = 53)
|
28 (52.8)
|
21 (39.6)
|
4 (7.5)
|
77 (72.6)
|
0.55
|
1.14 (0.73-1.79)
|
0.59
|
1.17 (0.66-2.05)
|
|
Serositis + (n = 55)
|
33 (60.0)
|
18 (32.7)
|
4 (7.3)
|
84 (76.4)
|
0.16
|
1.39 (0.88-2.20)
|
0.12
|
1.57 (0.89-2.75)
|
|
Anti-dsDNA Ab + (n = 280)
|
169 (60.4)
|
93 (33.2)
|
18 (6.4)
|
431 (77.0)
|
0.0026
|
1.44 (1.14-1.83)
|
0.0021
|
1.59 (1.18-2.13)
|
|
Anti-Sm Ab + (n = 67)
|
37 (55.2)
|
26 (38.8)
|
4 (6.0)
|
100 (74.6)
|
0.26
|
1.27 (0.84-1.91)
|
0.33
|
1.29 (0.77-2.15)
|
|
Onset <20 yr (n = 86)
|
46 (53.5)
|
34 (39.5)
|
6 (7.0)
|
126 (73.3)
|
0.37
|
1.18 (0.82-1.70)
|
0.43
|
1.20 (0.76-1.90)
|
|
Healthy controls (n = 513)
|
251 (48.9)
|
215 (41.9)
|
47 (9.2)
|
717 (69.9)
| |
reference
| |
reference
|
- OR: odds ratio, 95% CI: confidence interval. Genotype and allele frequencies are shown in parentheses (%).
- Association was tested by χ2 analysis using 2 × 2 contingency tables. All SLE group as well as each SLE subset was compared with healthy controls.
- *Association was tested under the recessive model for rs7708392C allele.
