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Table 2 Association study of TNIP1 rs7708392 with SLE in a Japanese population

From: Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study

 

Genotype

Allele

Allelic association

Recessive model*

 

C/C

C/G

G/G

C

P

OR (95%CI)

P

OR (95%CI)

All SLE (n = 364)

216 (59.3)

125 (34.3)

23 (6.3)

557 (76.5)

0.0022

1.40 (1.13-1.74)

0.0023

1.52 (1.16-2.00)

SLE subsets

        

   Renal disorder + (n = 203)

126 (62.1)

68 (33.5)

9 (4.4)

320 (78.8)

0.00065

1.60 (1.22-2.10)

0.0015

1.71 (1.23-2.38)

   Neurologic disorder + (n = 53)

28 (52.8)

21 (39.6)

4 (7.5)

77 (72.6)

0.55

1.14 (0.73-1.79)

0.59

1.17 (0.66-2.05)

   Serositis + (n = 55)

33 (60.0)

18 (32.7)

4 (7.3)

84 (76.4)

0.16

1.39 (0.88-2.20)

0.12

1.57 (0.89-2.75)

   Anti-dsDNA Ab + (n = 280)

169 (60.4)

93 (33.2)

18 (6.4)

431 (77.0)

0.0026

1.44 (1.14-1.83)

0.0021

1.59 (1.18-2.13)

   Anti-Sm Ab + (n = 67)

37 (55.2)

26 (38.8)

4 (6.0)

100 (74.6)

0.26

1.27 (0.84-1.91)

0.33

1.29 (0.77-2.15)

   Onset <20 yr (n = 86)

46 (53.5)

34 (39.5)

6 (7.0)

126 (73.3)

0.37

1.18 (0.82-1.70)

0.43

1.20 (0.76-1.90)

Healthy controls (n = 513)

251 (48.9)

215 (41.9)

47 (9.2)

717 (69.9)

 

reference

 

reference

  1. OR: odds ratio, 95% CI: confidence interval. Genotype and allele frequencies are shown in parentheses (%).
  2. Association was tested by χ2 analysis using 2 × 2 contingency tables. All SLE group as well as each SLE subset was compared with healthy controls.
  3. *Association was tested under the recessive model for rs7708392C allele.
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Arthritis Research & Therapy

ISSN: 1478-6362

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