Table 1 Results of association testing of previously reported CeD-associated loci with RA susceptibility
SNP | CHR | position | Gene | MAF cases | MAF controls | P_HWE | case_11 | case_12 | case_22 | control_11 | control_12 | control_22 | P_trend | Allelic OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs2816316 | 1 | 190803436 | RGS1 | 0.17 | 0.18 | 0.31 | 119 (3.3) | 1027 (28.2) | 2501 (68.6) | 99 (3.4) | 835 (28.5) | 1993 (68.1) | 0.65 | 0.98 (0.89 to 1.07) |
rs917997 | 2 | 102437000 | IL18RAP | 0.23 | 0.22 | 0.87 | 208 (5.7) | 1,285 (35.2) | 2,154 (59.1) | 147 (5.0) | 1,013 (34.6) | 1,771 (60.4) | 0.17 | 1.06 (0.98 to 1.15) |
rs6441961 | 3 | 46327388 | CCR3 | 0.31 | 0.31 | 0.76 | 350 (9.6) | 1,582 (43.3) | 1,720 (47.1) | 280 (9.6) | 1,239 (42.3) | 1,409 (48.1) | 0.52 | 1.03 (0.95 to 1.1) |
rs333 | 3 | 46389951 | CCR5 | 0.1 | 0.11 | 0.38 | 23 (0.7) | 689 (19.6) | 2,802 (79.7) | 35 (1.1) | 642 (20.6) | 2,444 (78.3) | 0.08 | 0.91 (0.81 to 1.01) |
rs17810546 | 3 | 161147744 | IL12A | 0.12 | 0.12 | 0.66 | 52 (1.4) | 736 (20.2) | 2,862 (78.4) | 45 (1.5) | 616 (21.1) | 2,264 (77.4) | 0.32 | 0.95 (0.85 to 1.05) |
rs1464510 | 3 | 189595248 | LPP | 0.45 | 0.44 | 0.72 | 697 (19.9) | 1,730 (49.4) | 1,077 (30.7) | 617 (19.9) | 1,524 (49.1) | 966 (31.1) | 0.82 | 1.01 (0.94 to 1.08) |
rs182429 | 6 | 159389562 | TAGAP | 0.42 | 0.45 | 0.82 | 600 (17.0) | 1,770 (50.2) | 1,159 (32.8) | 590 (20.5) | 1,421 (49.3) | 870 (30.2) | 0.0005 | 0.88 (0.82 to 0.95) |
rs653178# | 12 | 110492139 | SH2B3 | 0.49 | 0.51 | 0.68 | 914 (25.1) | 1,744 (47.9) | 985 (27.0) | 771 (26.4) | 1,449 (49.6) | 703 (24.1) | 0.02 | 0.92 (0.86 to 0.98) |