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Table 1 Results of association testing of previously reported CeD-associated loci with RA susceptibility

From: Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease

SNP CHR position Gene MAF cases MAF controls P_HWE case_11 case_12 case_22 control_11 control_12 control_22 P_trend Allelic OR (95% CI)
rs2816316 1 190803436 RGS1 0.17 0.18 0.31 119
(3.3)
1027
(28.2)
2501
(68.6)
99
(3.4)
835
(28.5)
1993
(68.1)
0.65 0.98
(0.89 to 1.07)
rs917997 2 102437000 IL18RAP 0.23 0.22 0.87 208
(5.7)
1,285
(35.2)
2,154
(59.1)
147
(5.0)
1,013
(34.6)
1,771
(60.4)
0.17 1.06
(0.98 to 1.15)
rs6441961 3 46327388 CCR3 0.31 0.31 0.76 350
(9.6)
1,582
(43.3)
1,720
(47.1)
280
(9.6)
1,239
(42.3)
1,409
(48.1)
0.52 1.03
(0.95 to 1.1)
rs333 3 46389951 CCR5 0.1 0.11 0.38 23
(0.7)
689
(19.6)
2,802
(79.7)
35
(1.1)
642
(20.6)
2,444
(78.3)
0.08 0.91
(0.81 to 1.01)
rs17810546 3 161147744 IL12A 0.12 0.12 0.66 52
(1.4)
736
(20.2)
2,862
(78.4)
45
(1.5)
616
(21.1)
2,264
(77.4)
0.32 0.95
(0.85 to 1.05)
rs1464510 3 189595248 LPP 0.45 0.44 0.72 697
(19.9)
1,730
(49.4)
1,077
(30.7)
617
(19.9)
1,524
(49.1)
966
(31.1)
0.82 1.01
(0.94 to 1.08)
rs182429 6 159389562 TAGAP 0.42 0.45 0.82 600
(17.0)
1,770
(50.2)
1,159
(32.8)
590
(20.5)
1,421
(49.3)
870
(30.2)
0.0005 0.88
(0.82 to 0.95)
rs653178# 12 110492139 SH2B3 0.49 0.51 0.68 914
(25.1)
1,744
(47.9)
985
(27.0)
771
(26.4)
1,449
(49.6)
703
(24.1)
0.02 0.92
(0.86 to 0.98)
  1. # r2 = 1 with rs3184504; 11 = homozygote for minor allele, 12 = heterozygote, 22 = homozygote for major allele; CHR, chromosome; MAF, minor allele frequency; P_HWE, P-value for Hardy Weinberg equilibrium test