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Table 1 Results of association testing of previously reported CeD-associated loci with RA susceptibility

From: Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease

SNP CHR position Gene MAF cases MAF controls P_HWE case_11 case_12 case_22 control_11 control_12 control_22 P_trend Allelic OR (95% CI)
rs2816316 1 190803436 RGS1 0.17 0.18 0.31 119 (3.3) 1027 (28.2) 2501 (68.6) 99 (3.4) 835 (28.5) 1993 (68.1) 0.65 0.98 (0.89 to 1.07)
rs917997 2 102437000 IL18RAP 0.23 0.22 0.87 208 (5.7) 1,285 (35.2) 2,154 (59.1) 147 (5.0) 1,013 (34.6) 1,771 (60.4) 0.17 1.06 (0.98 to 1.15)
rs6441961 3 46327388 CCR3 0.31 0.31 0.76 350 (9.6) 1,582 (43.3) 1,720 (47.1) 280 (9.6) 1,239 (42.3) 1,409 (48.1) 0.52 1.03 (0.95 to 1.1)
rs333 3 46389951 CCR5 0.1 0.11 0.38 23 (0.7) 689 (19.6) 2,802 (79.7) 35 (1.1) 642 (20.6) 2,444 (78.3) 0.08 0.91 (0.81 to 1.01)
rs17810546 3 161147744 IL12A 0.12 0.12 0.66 52 (1.4) 736 (20.2) 2,862 (78.4) 45 (1.5) 616 (21.1) 2,264 (77.4) 0.32 0.95 (0.85 to 1.05)
rs1464510 3 189595248 LPP 0.45 0.44 0.72 697 (19.9) 1,730 (49.4) 1,077 (30.7) 617 (19.9) 1,524 (49.1) 966 (31.1) 0.82 1.01 (0.94 to 1.08)
rs182429 6 159389562 TAGAP 0.42 0.45 0.82 600 (17.0) 1,770 (50.2) 1,159 (32.8) 590 (20.5) 1,421 (49.3) 870 (30.2) 0.0005 0.88 (0.82 to 0.95)
rs653178# 12 110492139 SH2B3 0.49 0.51 0.68 914 (25.1) 1,744 (47.9) 985 (27.0) 771 (26.4) 1,449 (49.6) 703 (24.1) 0.02 0.92 (0.86 to 0.98)
  1. # r2 = 1 with rs3184504; 11 = homozygote for minor allele, 12 = heterozygote, 22 = homozygote for major allele; CHR, chromosome; MAF, minor allele frequency; P_HWE, P-value for Hardy Weinberg equilibrium test