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Table 2 Heritability estimates for radiographic phenotypes, after adjustment for age, gender and body mass index

From: Heritability patterns in hand osteoarthritis: the role of osteophytes

 

All subjects

Caucasians only

Phenotype

Heritability estimate (SE)

Pvalue

Heritability estimate (SE)

Pvalue

First IP count

0.63 (0.15)

0.00004

0.70 (0.15)

0.00001

DIP count

0.36 (0.1643)

0.02

0.36 (0.17)

0.019

PIP counta

0.30 (0.16)

0.03

0.28 (0.17)

0.04

DIP/IP/PIP counta

0.42 (0.16)

0.004

0.41 (0.16)

0.006

CMC count

0.38 (0.17)

0.01

0.46 (0.17)

0.005

Total counta

0.38 (0.16)

0.008

0.38 (0.16)

0.01

First IP scorea

0.84 (0.14)

0.0000001

0.89 (0.14)

2.70 × 10-9

DIP scorea

0.18 (0.16)

0.12

0.16 (0.17)

0.17

PIP scorea

0.16 (0.15)

0.15

0.14 (0.16)

0.18

DIP/IP/PIP scorea

0.33 (0.16)

0.02

0.33 (0.16)

0.02

CMC score

0.53 (0.16)

0.0006

0.63 (0.16)

0.0001

Total scorea

0.35 (0.16)

0.01

0.36 (0.16)

0.01

Subchondral cystsa

0.17 (0.15)

0.13

0.13 (0.16)

0.20

Joint subluxationa

0.27 (0.17)

0.06

0.19 (0.19)

0.15

Joint space narrowinga

0.24 (0.16)

0.06

0.18 (0.17)

0.14

Subchondral sclerosisa

0.17 (0.16)

0.14

0.15 (0.17)

0.18

Erosionsa

0.12 (0.14)

0.20

0.13 (0.15)

0.20

Joint deformitya

0.31 (0.20)

0.06

0.15 (0.20)

0.24

Heberden's nodes

0.36 (0.22)

0.07

0.21 (0.23)

0.19

  1. CMC, carpometacarpal joint; DIP, distal interphalangeal joint; IP, interphalangeal joint; PIP, proximal interphalangeal joint; SE, standard error. aTransformed by square root. Statistically significant results are represented in bold.