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Table 1 Baseline demographics and disease characteristics

From: A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis

   AMG 108
  Placebo
(n= 203)
50 mg
(n= 204)
125 mg
(n= 203)
250 mg
(n= 203)
Total
(n= 610)
Mean age (years) 52.1 51.4 51.7 52.2 51.8
Age group, n (%)      
   < 65 years 185 (91.1) 171 (83.8) 176 (86.7) 184 (90.6) 531 (87.0)
   ≥65 years 18 (8.9) 33 (16.2) 27 (13.3) 19 (9.4) 79 (13.0)
Female, n (%) 158 (77.8) 155 (76.0) 163 (80.3) 160 (78.8) 478 (78.4)
Ethnicity, n (%)      
   White 168 (82.8) 169 (82.8) 177 (87.2) 179 (88.2) 525 (86.1)
   Hispanic 27 (13.3) 24 (11.8) 18 (8.9) 17 (8.4) 59 (9.7)
   Othera 8 (3.9) 11 (5.4) 8 (3.9) 7 (3.4) 26 (4.3)
Mean weight (kg) 76.4 77.2 74.2 75.0 75.4
Mean height (cm) 164.0 164.6 164.0 164.8 164.5
Mean body mass index (kg/m2) 28.4 28.4 27.5 27.5 27.8
Mean duration of RA (years) 7.6 7.3 7.5 8.0 7.6
Subcomponent of ACR (mean)      
   Tender joint count 26.3 26.5 24.8 26.9 26.1
   Swollen joint count 16.8 16.8 15.8 15.7 16.1
   Patient global assessment 5.9 6.2 6.1 6.1 6.2
   Physician global assessment 6.2 6.3 6.3 6.5 6.4
   Patient pain assessment 51.2 53.9 53.5 57.0 54.8
HAQ Disability Index 1.4 1.5 1.5 1.5 1.5
C-reactive protein (mg/dl) 1.2 1.8 1.5 1.4 1.6
ESR (mm/hour) 33.4 40.1 35.6 35.5 37.1
Mean DAS28 CRP 4.7 4.9 4.7 4.8 4.8
Mean DAS28 ESR 5.3 5.4 5.3 5.4 5.3
Mean tender joint count (28 joints) 14.0 14.5 13.5 14.0 14.0
Mean swollen joint count (28 joints) 11.3 10.6 10.8 11.2 11.0
  1. ACR, American College of Rheumatology; DAS28, Disease Activity Score (28-joint count); ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; RA, rheumatoid arthritis. aBlack, Asian, American Indian or Alaska native, native Hawaiian or other Pacific Islander.