Table 3 Improvements in American College of Rheumatology and DAS28 components at week 24
| Â | Â | AMG 108 | ||
|---|---|---|---|---|
| Â | Placebo (n= 203) | 50 mg (n= 204) | 125 mg (n= 203) | 250 mg (n= 203) |
Tender joint count (68 joints) | Â | Â | Â | Â |
   Mean (SD) % change | -20.0 (127.5) | -29.5 (60.4) | -35.7 (43.6) | -40.2 (44.3) |
   Median % change | -31.3 | -38.4 | -40.0 | -46.7 |
Swollen joint count (66 joints) | Â | Â | Â | Â |
   Mean (SD) % change | -32.2 (50.0) | -33.7 (46.5) | -33.8 (114.8) | -39.1 (53.3) |
   Median % change | -33.1 | -40.8 | -46.3 | -47.1 |
Patient global assessment | Â | Â | Â | Â |
   Mean (SD) % change | -11.6 (49.8) | -16.7 (43.8) | -21.6 (48.2) | -17.8 (64.5) |
   Median % change | -20.0 | -16.7 | -28.6 | -20.0 |
Physician global assessment | Â | Â | Â | Â |
   Mean (SD) % change | -30.1 (33.7) | -36.0 (30.4) | -36.2 (33.2) | -43.0 (30.8) |
   Median % change | -33.3 | -37.5 | -40.0 | -50.0 |
Pain (visual analog scale) | Â | Â | Â | Â |
   Mean (SD) % change | 2.2 (142.6) | -11.4 (76.3) | -20.6 (60.6) | -30.9 (46.9) |
   Median % change | -12.8 | -20.0 | -28.9 | -34.7 |
HAQ Disability Index | Â | Â | Â | Â |
   Mean (SD) % change | -11.1 (53.0) | -12.2 (40.6) | -20.5 (48.2) | -25.2 (44.6) |
   Median % change | -11.4 | -13.3 | -20.0 | -25.0 |
Erythrocyte sedimentation rate | Â | Â | Â | Â |
   Mean (SD) % change | 12.7 (77.7) | 5 (124.3) | -18.3 (68.7) | -30.4 (73.7) |
   Median % change | -6.3 | -13.2 | -36.8 | -46.7 |
C-reactive protein | Â | Â | Â | Â |
   Mean (SD) % change | 123.2 (695.3) | 32.2 (164.0) | -1.9 (181.5) | -25.5 (168.5) |
   Median % change | 5.1 | -12.4 | -41.2 | -59.4 |
Tender joint count (28 joints) | Â | Â | Â | Â |
   Mean (SD) % change | -13.2 (143.7) | -21.0 (73.2) | -31.6 (58.7) | -36.5 (65.7) |
   Median % change | -33.3 | -33.3 | -40.0 | -44.4 |
Swollen joint count (28 joints) | Â | Â | Â | Â |
   Mean (SD) % change | -28.2 (52.7) | -30.0 (48.1) | -28.7 (118.3) | -38.0 (52.2) |
   Median % change | -33.3 | -33.3 | -44.4 | -44.4 |