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Table 3 Improvements in American College of Rheumatology and DAS28 components at week 24

From: A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis

   AMG 108
  Placebo
(n= 203)
50 mg
(n= 204)
125 mg
(n= 203)
250 mg
(n= 203)
Tender joint count (68 joints)     
   Mean (SD) % change -20.0 (127.5) -29.5 (60.4) -35.7 (43.6) -40.2 (44.3)
   Median % change -31.3 -38.4 -40.0 -46.7
Swollen joint count (66 joints)     
   Mean (SD) % change -32.2 (50.0) -33.7 (46.5) -33.8 (114.8) -39.1 (53.3)
   Median % change -33.1 -40.8 -46.3 -47.1
Patient global assessment     
   Mean (SD) % change -11.6 (49.8) -16.7 (43.8) -21.6 (48.2) -17.8 (64.5)
   Median % change -20.0 -16.7 -28.6 -20.0
Physician global assessment     
   Mean (SD) % change -30.1 (33.7) -36.0 (30.4) -36.2 (33.2) -43.0 (30.8)
   Median % change -33.3 -37.5 -40.0 -50.0
Pain (visual analog scale)     
   Mean (SD) % change 2.2 (142.6) -11.4 (76.3) -20.6 (60.6) -30.9 (46.9)
   Median % change -12.8 -20.0 -28.9 -34.7
HAQ Disability Index     
   Mean (SD) % change -11.1 (53.0) -12.2 (40.6) -20.5 (48.2) -25.2 (44.6)
   Median % change -11.4 -13.3 -20.0 -25.0
Erythrocyte sedimentation rate     
   Mean (SD) % change 12.7 (77.7) 5 (124.3) -18.3 (68.7) -30.4 (73.7)
   Median % change -6.3 -13.2 -36.8 -46.7
C-reactive protein     
   Mean (SD) % change 123.2 (695.3) 32.2 (164.0) -1.9 (181.5) -25.5 (168.5)
   Median % change 5.1 -12.4 -41.2 -59.4
Tender joint count (28 joints)     
   Mean (SD) % change -13.2 (143.7) -21.0 (73.2) -31.6 (58.7) -36.5 (65.7)
   Median % change -33.3 -33.3 -40.0 -44.4
Swollen joint count (28 joints)     
   Mean (SD) % change -28.2 (52.7) -30.0 (48.1) -28.7 (118.3) -38.0 (52.2)
   Median % change -33.3 -33.3 -44.4 -44.4
  1. DAS28, Disease Activity Score (28-joint count); HAQ, health assessment questionnaire; SD, standard deviation.