| Polyarticular u-PA is deleteriousa | Monoarticular u-PA is protectiveb |
---|---|---|
Induction | Systemic (intra-dermal, intravenous, and intraperitoneal) | Intra-articular |
Models | ||
Mechanism of arthritis development | Immune complex-mediated and complement-dependent | Local trauma, increased fibrin deposition, and 'wound healing-like' process |