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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits

Figure 6

Possible mechanism of prevention for intervertebral disc degeneration by intradiscal transplantation of synovial MSCs. After aspiration of the nucleus pulposus, intervertebral disc space rapidly decreases. Synovial MSCs injected into the nucleus pulposus space promote synthesis of type II collagen for the remaining nucleus pulposus cells. Also, synovial MSCs affected the remaining nucleus pulposus cells by inhibiting expressions of degradative enzymes and inflammatory cytokines, resulting in maintaining the structure of the vertebral disc.

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