| ACR 20 | ACR 50 | DAS 28 | |||
---|---|---|---|---|---|---|
 | OR | P | OR | P | OR | P |
Training subset | Â | Â | Â | Â | Â | Â |
Baseline | Â | Â | Â | Â | Â | Â |
Pyridinoline | 0.101 | 0.004 | 0.383 | NS | 0.150 | NS |
von Willebrand factor | 0.444 | 0.048 | 0.366 | 0.026 | 0.420 | NS |
Change from baseline to week 4 | Â | Â | Â | Â | Â | Â |
α1-Antitrypsin | 0.025 | 0.009 | 1.021 | NS | 0.138 | NS |
Complement 3 | 0.007 | 0.006 | 0.707 | NS | 0.324 | NS |
ENRAGE (S100A12) | 0.455 | 0.015 | 0.841 | NS | 0.381 | 0.030 |
Haptoglobin | 0.131 | 0.003 | 0.693 | NS | 0.276 | 0.033 |
Hyaluronic acid | 0.343 | 0.006 | 0.975 | NS | 0.511 | NS |
Interleukin-8 | 0.483 | NS | 0.472 | 0.020 | 0.572 | NS |
Interleukin-16 | 0.121 | 0.012 | 1.041 | NS | 0.096 | 0.015 |
Matrix metalloproteinase-3 | 0.318 | 0.008 | 1.102 | NS | 0.283 | NS |
Plasminogen activator-1 | 0.114 | 0.041 | 0.713 | NS | 0.442 | NS |
Pyridinoline | 3.744 | NS | 0.212 | 0.044 | 23.610 | NS |
Serum amyloid P | 0.057 | 0.006 | 0.650 | NS | 0.075 | 0.035 |
Thyroxine-binding globulin | 0.008 | 0.008 | 2.093 | NS | 0.221 | NS |
Test subset | Â | Â | Â | Â | Â | Â |
Baseline | Â | Â | Â | Â | Â | Â |
Apolipoprotein C3 | 0.753 | NS | 0.510 | 0.006 | 0.930 | NS |
Hyaluronic acid | 1.347 | 0.001 | 1.228 | 0.037 | 1.102 | NS |
Interleukin-6 | 1.199 | 0.024 | 1.232 | 0.027 | 1.052 | NS |
Interleukin-8 | 0.880 | NS | 0.970 | NS | 0.802 | 0.042 |
Matrix metalloproteinase-3 | 1.240 | 0.026 | 1.181 | NS | 1.087 | NS |
Myeloperoxidase | 0.821 | NS | 0.934 | NS | 0.694 | 0.020 |
Change from baseline to week 4 | Â | Â | Â | Â | Â | Â |
α1-Antitrypsin | 0.505 | NS | 0.298 | 0.035 | 0.301 | 0.033 |
Apolipoprotein C3 | 2.191 | 0.014 | 1.681 | NS | 1.741 | NS |
Basic fibroblast growth factor | 0.353 | 0.007 | 0.484 | 0.042 | 0.424 | 0.012 |
Carcinoembryonic antigen | 2.674 | NS | 1.89 | NS | 3.891 | 0.020 |
C-reactive protein | 0.714 | <0.001 | 0.652 | <0.001 | 0.728 | 0.002 |
ENRAGE (S100A12) | 0.642 | 0.005 | 0.568 | 0.001 | 0.767 | NS |
Haptoglobin | 0.497 | 0.004 | 0.417 | <0.001 | 0.474 | 0.008 |
Hyaluronic acid | 0.513 | <0.001 | 0.514 | <0.001 | 0.699 | 0.017 |
Interleukin-6 | 0.623 | <0.001 | 0.665 | <0.001 | 0.733 | 0.003 |
Interleukin-16 | 0.371 | 0.007 | 0.234 | <0.001 | 0.422 | 0.029 |
Intracellular adhesion molecule-1 | 0.654 | NS | 0.673 | NS | 0.468 | 0.030 |
Lipoprotein (a) | 0.727 | NS | 0.460 | 0.045 | 0.748 | NS |
Matrix metalloproteinase-3 | 0.539 | 0.001 | 0.570 | 0.005 | 0.673 | 0.043 |
Macrophage inflammatory protein 1-α | 0.687 | NS | 0.454 | 0.041 | 0.903 | NS |
Serum amyloid P | 0.628 | NS | 0.304 | 0.015 | 0.346 | 0.025 |
Stem cell factor | 2.239 | 0.028 | 1.521 | NS | 1.383 | NS |
Tissue inhibitor of metalloproteinases-1 | 0.595 | NS | 0.264 | 0.035 | 0.603 | NS |
Vascular endothelial growth factor | 0.419 | 0.009 | 0.326 | 0.004 | 0.307 | 0.002 |