Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study

Table 4 Odds ratios for associations between biomarker levels (baseline and changes from baseline to week 4) and outcome measures of fatigue (FACIT-F) and health-related quality of life (SF-36) at week 14 for the training and test golimumab/golimumab + MTX datasets

	FACIT-F		SF-36 PCS		SF-36 MCS
	OR	P	OR	P	OR	P
Training subset
Baseline
von Willebrand factor	0.380	0.021	0.427	0.039	0.370	0.019
Change from baseline to week 4
ENRAGE (S100A12)	0.578	0.053	0.549	0.044	0.603	0.070
Matrix metalloproteinase-3	0.529	0.041	0.621	0.122	1.000	0.999
Test subset
Baseline
Matrix metalloproteinase-3	1.233	0.035	0.922	0.409	0.972	0.775
Tissue inhibitor of metalloproteinase-1	0.925	0.843	0.375	0.017	0.798	0.567
Change from baseline to week 4
C-reactive protein	0.879	0.122	0.772	0.003	0.833	0.033
Matrix metalloproteinase-3	0.893	0.522	0.811	0.248	0.615	0.010
All data combined
Baseline
α₁-antitrypsin	1.206	0.479	0.567	0.037	1.230	0.436
Intracellular adhesion molecule-1	1.166	0.484	0.611	0.046	1.451	0.117
Tissue inhibitor of metalloprotienases-1	0.833	0.583	0.342	0.002	0.843	0.610
von Willebrand factor	0.949	0.775	0.628	0.017	0.760	0.146
Change from baseline to week 4
C-reactive protein	0.910	0.176	0.831	0.011	0.940	0.370
ENRAGE (S100A12)	0.761	0.040	0.710	0.011	0.821	0.135
Interleukin-6	0.953	0.543	0.846	0.039	0.965	0.651
Matrix metalloprotienase-3	0.810	0.173	0.784	0.121	0.669	0.013

Odds ratios show association between biomarker levels (baseline or changes from baseline to week 4) and whether FACIT-F, SF-36 mental component summary score, or SF-36 physical component summary score was above or below the median. Only biomarkers for which at least one association was <0.05 are shown. FACIT-F, Functional Assessment of Chronic Illness Therapy -Fatigue; SF-36, 36-question Short Form Survey; OR, odds ratio; MCS, mental component summary score; PCS, physical component summary score.

ISSN: 1478-6362