Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus

Supplementary Table 2 Demographics and clinical features of 576 SLE patients

	Sibpair	Trio
Number of families	210	122
Number of affected individuals (sex, F:M)	440:10	123:0
Family ethnicity
White	78	96
African-American	10	1
Hispanic	7	1
Asian	2	1
Mixed heritage	3	1
Laboratory/clinical features^† (%)
ANA positive	98	97
Anti-dsDNA positive	46	72^***
Arthritis	85	84
Skin involvement	92	82^**
Pleuritis	53	45^*
Hematologic	48	72^***
Renal disease	33	53^***
CNS lupus	25	15^**
Pericarditis	19	20

^†Data represent the percentage of SLE patients having the indicated laboratory/clinical features at any time during the course of their disease. Differences in the clinical features between the trio and sibpair familiy collections were determined using generalized estimating equations to adjust for intrafamilial correlation within the sibpair families [S15]. ^***P <0.0001, ^**P <0.01, ^*P <0.05. ANA = antinuclear antibodies; CNS = central nervous system

ISSN: 1478-6362