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Table 2 Association of GSTM1-null, HLA-DRB1 shared epitope (SE) and smoking with ACPA positivity in rheumatoid arthritisa

From: Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferasein a cross-sectional study

  VARA (n= 703) SONORA (n= 610)
  ACPA+ (%) OR (95% CI) Pvalue ACPA+ (%) OR (95% CI) Pvalue
GSTM1-present 73 Ref. - 69 Ref. -
GSTM1-null 79 1.45 (1.02 to 2.05) 0.039 69 1.00 (0.71 to 1.42) 0.981
Never smoking 69 Ref. - 69 Ref. -
Ever smoking 78 1.48 (0.97 to 2.26) 0.067 68 0.90 (0.62 to 1.30) 0.574
Former smoking 77 1.41 (0.91 to 2.19) 0.129 65 0.77 (0.52 to 1.14) 0.193
Current smoking 81 1.68 (0.98 to 2.88) 0.059 74 1.23 (0.76 to 1.99) 0.407
SE-negative 53 Ref. - 54 Ref. -
SE-positive (one or two alleles) 84 4.36 (2.98 to 6.37) < 0.001 75 2.56 (1.77 to 3.70) < 0.001
SE-positive (one allele) 79 3.23 (2.17 to 4.81) < 0.001 68 1.77 (1.21 to 2.60) 0.003
SE-positive (two alleles) 93 10.65 (5.61 to 20.20) < 0.001 92 10.27 (5.05 to 20.89) < 0.001
  1. aACPA, anticitrullinated protein antibody; CI, confidence interval; GSTM1, glutathione S-transferase Mu-1; OR, odds ratio; SE, shared epitope; SONORA, Study of New-Onset Rheumatoid Arthritis; VARA, Veterans Affairs Rheumatoid Arthritis Registry. All analyses are age- and gender-adjusted. "Ref." = referent group in each analysis.