Figure 1

Pleiotropic functions of TNF and TNF receptor. TACE, TNF alpha converting enzyme; tmTNF, transmembrane TNF; TNF, tumour necrosis factor; sTNF, soluble TNF; RA, rheumatoid arthritis; IBD, inflammatory bowel disease; MS, multiple sclerosis; IDDM, insulin-dependent diabetes mellitus; SLE, systemic lupus erythematosus. Figure kindly provided by Dr George Kollias (Athens, Greece).