Figure 5

Mapping of major citrullinated fibrinogen epitopes recognized by RA sera. The citrullinated peptides present in the most strongly reactive fractions are schematically aligned with the α- and β-chains of fibrinogen. Asterisks indicate the citrullinated residues in the peptides. Citrullinated peptides (obtained by in vitro citrullination with rmPAD2) that are present in the most reactive fractions of at least two of the three proteolytic digests are highlighted in dark grey, whereas the other peptides in these fractions are indicated with the light grey boxes.