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Table 2 Citrullinated fibrinogen epitopes detected also in previous studies

From: Mapping of citrullinated fibrinogen B-cell epitopes in rheumatoid arthritis by imaging surface plasmon resonance

Reference

Peptide useda

Citrullination sites

Fibrinogen chain

Percentage of reactive sera (%)

Sebbag et al. [4].

___________R D R QHLPLIKMKPVP

216, 218

α

0

 

_________LPS R D R QHLPLIKMK

216, 218

α

0

Perez et al. [9].

____IAKDLLPS R DRQHLPLIK

216

α

18

 

____IAKDLLPSRD R QHLPLIK

218

α

0

 

____IAKDLLPS R D R QHLPLIK

216, 218

α

0

Sebbag et al. [4].

_____________SSHHPGIAEFP R GK

573

α

25

Kubota et al. [15].

___SGIFTNTKESSSHHPGIAEFP R GKSSSY

573

α

n.d.

Nakayama-Hamada et al. [16].

b)

573

α

n.d.

Sebbag et al. [4].

_____________R GDSTFESKSYKMAD

591

α

0

 

__________SYN R GDSTFESKSYK

591

α

20

Kubota et al. [15].

____QFTSSTSYN R GDSTFESKS

591

α

n.d.

Nakayama-Hamada et al. [16].

b)

591

α

n.d.

Perez et al. [9].

A R GH R PLDKK R EEAPSL R PA

44, 47, 53, 60

β

3

 

ARGH R PLDKK R EEAPSL R PA

47, 53, 60

β

9

 

A R GHRPLDKK R EEAPSL R PA

44, 53, 60

β

6

Sebbag et al. [4].

_______DKK R EEAPSL R PAPP

53,60

β

0

Perez et al. [9].

ARGHRPLDKK R EEAPSL R PA

53,60

β

12

 

ARGHRPLDKKREEAPSL R PA

60

β

12

 

A R GHRPLDKKREEAPSL R PA

44, 60

β

0

 

ARGH R PLDKKREEAPSL R PA

47, 60

β

36

 

A R GH R PLDKKREEAPSL R PA

44, 47, 60

β

12

 

______________R ARPAKAAATQKKVERKA

72

β

0

 

______________RA R PAKAAATQKKVERKA

74

β

0

Sebbag et al. [4].

__R PAPPPISGGGY R A R

60, 72, 74

β

28

Hill et al. [7].

___________GGY R A R PAKAAAT

72, 74

β

0

Perez et al. [9].

_____________R A R PAKAAATQKKVERKA

72, 74

β

0

Nakayama-Hamada et al. [16].

b)

53, 60, 72, 74

β

n.d.

Perez et al. [9].

_____________R ARPAKAAATQKKVE R KA

72, 87

β

0

 

_____________RA R PAKAAATQKKVE R KA

74, 87

β

0

 

_____________R A R PAKAAATQKKVE R KA

72, 74, 87

β

0

  1. a) Arginines that can be citrullinated by either hPAD2, hPAD4 or rmPAD2 are highlighted in bold.
  2. b) Nakayama-Hamada and colleagues only showed the identified citrullination sites and not which peptides containing the sites were found.
  3. n.d.: not determined