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Table 3 Demographic and clinical characteristics at baseline

From: Surprising negative association between IgG1 allotype disparity and anti-adalimumab formation: a cohort study

 

G1m phenotype

 

3,3

3,17

17,17

 

n = 120

n = 98

n = 32

Demographics

   

Age, years

53 ± 14

53 ± 12*

48 ± 12*

Female, no. (%)

95 (79)

74 (76)

28 (88)

DMARD therapy

   

Prior DMARDs (no.)

3.5 ± 1.6

3.4 ± 1.7

3.3 ± 1.6

Methotrexate use, no. (%)

95 (79)

81 (83)

23 (72)

Methotrexate dose (mg/wk)

21 (15 to 25)

25 (15 to 25)

25 (17.5 to 25)

Prednisone use, no. (%)

39 (33)

31 (32)

12 (38)

Prednisone dose (mg/day)

7.5 (5 to 10)

5 (5 to 7.5)

10 (5 to 10)

Disease status

   

Disease duration (years)

10 (4 to 17)

11 (3 to 16)

7 (3 to 17)

Rheumatoid factor positive, no. (%)

80 (67)*

70 (71)

29 (91)*

Erosive disease, no. (%)

90 (75)

76 (78)

28 (88)

Erythrocyte sedimentation rate (mm/h)

29 ± 23

31 ± 25

28 ± 17

C-reactive protein (mg/dl)

11 (4 to 24)

10 (6 to 23)

14 (6 to 31)

DAS28

5.1 ± 1.2

5.3 ± 1.2

5.2 ± 1.0

  1. DAS28, Disease Activity Score in 28 joints; DMARD, diseases modifying anti rheumatic drug.
  2. *There was a significant difference between patients with the 3,17-allotype and the 17,17-allotype for age (P = 0.020), and between both homozygous groups 3,3 and 17,17 for rheumatoid factor positivity, no. (P = 0.007).