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Table 2 Association between BMLs and cartilage defects

From: Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults

  Multivariable OR (95% CI)† Multivariable OR (95% CI)‡
BMLs predicting defect increases   
   Medial tibial BMLs 1.8 (1.2, 2.7)** 1.8 (1.1, 2.9)*
   Medial femoral BMLs 2.3 (1.5, 3.5)** 2.2 (1.4, 3.5)**
   Lateral tibial BMLs 2.8 (1.8, 4.5)** 3.2 (1.9, 5.4)**
   Lateral femoral BMLs 3.3 (2.1, 5.0)** 3.0 (1.9, 4.8)**
Defects predicting BML increases   
   Medial tibial defects 3.7 (2.1, 6.5)** 3.3 (1.6, 6.8)**
   Medial femoral defects 2.2 (1.3, 3.8)** 2.0 (1.0, 4.1)
   Lateral tibial defects 2.5 (1.5, 4.2)** 1.6 (0.8, 3.4)
   Lateral femoral defects 2.6 (1.6, 4.2)** 3.7 (1.9, 7.3)**
  1. Baseline BMLs (0 to 3) and site-specific increases in cartilage defects at the same site and baseline cartilage defects (0 to 4) and site-specific increases in BMLs at the same site.
  2. Bold denotes a statistically significant result. *P < 0.05, **P < 0.01.
  3. † Adjusted for age, sex, body mass index and baseline site-specific defects if BMLs and site-specific BMLs if defects. All P-values < 0.01.
  4. ‡ Further adjusted for meniscal extrusion and meniscal tear.
  5. BMLs, bone marrow lesions; CI, confidence interval; OR, odds ratio.