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Table 3 Baseline BMLs (0 to 3) and baseline cartilage defects (0 to 4) predicting absolute changes in cartilage volume

From: Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults

  Multivariable β (95% CI)† Multivariable β (95% CI)‡
Medial tibial   
BMLs -24.5 (-47.0, -2.0)* -14.4 (-40.9, +12.1)
Cartilage defects -33.7 (-60.3, -7.1)* -5.0 (-43.6, +33.7)
Medial femoral   
BMLs -42.0 (-63.6, -20.5)** -42.0 (-63.7, -20.4)**
Cartilage defects -17.2 (-34.7, +0.4) -17.2 (-34.8, +0.4)#
Lateral tibial   
BMLs -35.2 (-56.1, -14.4)** -35.5 (-58.5, -12.6)**
Cartilage defects -12.6 (-34.2, +9.0) -21.7 (-50.2, +6.8)
Lateral femoral   
BMLs -22.1 (-39.5, -4.7)* -22.1 (-39.5, -4.7)*
Cartilage defects -12.3 (-29.7, +5.1) -12.3 (-29.7, +5.1)
  1. Bold denotes a statistically significant result. *P < 0.05, **P < 0.01.
  2. † Adjusted for age, sex, body mass index, baseline site-specific cartilage volume and defects if BMLs and BMLs if defects.
  3. ‡ Further adjusted for meniscal extrusion and meniscal tear.
  4. #P = 0.056
  5. β, beta-coefficient; BMLs, bone marrow lesions; CI, confidence interval.