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Table 3 Baseline BMLs (0 to 3) and baseline cartilage defects (0 to 4) predicting absolute changes in cartilage volume

From: Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults

 

Multivariable β (95% CI)†

Multivariable β (95% CI)‡

Medial tibial

  

BMLs

-24.5 (-47.0, -2.0)*

-14.4 (-40.9, +12.1)

Cartilage defects

-33.7 (-60.3, -7.1)*

-5.0 (-43.6, +33.7)

Medial femoral

  

BMLs

-42.0 (-63.6, -20.5)**

-42.0 (-63.7, -20.4)**

Cartilage defects

-17.2 (-34.7, +0.4)

-17.2 (-34.8, +0.4)#

Lateral tibial

  

BMLs

-35.2 (-56.1, -14.4)**

-35.5 (-58.5, -12.6)**

Cartilage defects

-12.6 (-34.2, +9.0)

-21.7 (-50.2, +6.8)

Lateral femoral

  

BMLs

-22.1 (-39.5, -4.7)*

-22.1 (-39.5, -4.7)*

Cartilage defects

-12.3 (-29.7, +5.1)

-12.3 (-29.7, +5.1)

  1. Bold denotes a statistically significant result. *P < 0.05, **P < 0.01.
  2. † Adjusted for age, sex, body mass index, baseline site-specific cartilage volume and defects if BMLs and BMLs if defects.
  3. ‡ Further adjusted for meniscal extrusion and meniscal tear.
  4. #P = 0.056
  5. β, beta-coefficient; BMLs, bone marrow lesions; CI, confidence interval.