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Table 4 Relationship between changes in the five WOMAC pain sub-scales and changes in BML size*

From: Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults

  BML size change at all 4 sites ** Total BML size change
  Univariate (95% CI) P Multivariable (95% CI)† P Univariate (95% CI) P Multivariable (95% CI)† P
No ROA         
   Walking on a flat surface 0.15 (0.05, 0.26) 0.005 0.14 (0.06, 0.22) 0.001 0.30 (0.05, 0.54) 0.018 0.29 (0.11, 0.48) 0.002
   Going up and down stairs 0.16 (0.04, 0.28) 0.008 0.15 (0.05, 0.25) 0.003 0.33 (0.05, 0.60) 0.020 0.33 (0.09, 0.57) 0.006
   At night while in bed 0.13 (0.03, 0.23) 0.014 0.11 (0.04, 0.18) 0.002 0.22 (-0.01, 0.45) 0.066 0.21 (0.04, 0.38) 0.014
   Sitting or lying 0.06 (-0.03, 0.15) 0.172 0.07 (-0.01, 0.15) 0.073 0.11 (-0.10, 0.31) 0.314 0.14 (-0.04, 0.33) 0.130
   Standing upright 0.06 (-0.03, 0.15) 0.160 0.08 (-0.001, 0.16) 0.054 0.12 (-0.09, 0.33) 0.271 0.16 (-0.03, 0.35) 0.089
ROA present         
   Walking on a flat surface -0.02 (0.08, 0.05) 0.652 -0.02 (0.08, 0.05) 0.617 -0.02 (-0.15, 0.10) 0.686 -0.03 (-0.14, 0.09) 0.645
   Going up and down stairs 0.02 (-0.07, 0.12) 0.660 0.02 (-0.06, 0.11) 0.601 0.03 (-0.14, 0.20) 0.722 0.03 (-0.12, 0.19) 0.673
   At night while in bed 0.03 (-0.07, 0.14) 0.534 0.01 (-0.07, 0.09) 0.871 0.05 (-0.14, 0.25) 0.589 0.01 (-0.13, 0.16) 0.850
   Sitting or lying 0.01 (-0.08, 0.10) 0.863 -0.01 (-0.08, 0.06) 0.827 0.01 (-0.15, 0.17) 0.895 -0.01 (-0.14, 0.12) 0.847
   Standing upright 0.03 (-0.05, 0.12) 0.431 0.01 (-0.06, 0.07) 0.800 0.05 (-0.10, 0.21) 0.504 0.01 (-0.11, 0.14) 0.814
  1. *Values are the change in pain sub-scale score per one standard deviation change in BML size (mm2), stratified by ROA.
  2. β, beta coefficients; 95% CI, 95% confidence interval; BML, bone marrow lesion; ROA, radiographic osteoarthritis; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.
  3. **Medial tibial, medial femoral, lateral tibial, and lateral femoral.
  4. † Adjusted for age, sex, body mass index, leg strength, quality of life, and baseline pain sub-scale score depending on the model. Boldface denotes statistically significant result.