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Table 4 Relationship between changes in the five WOMAC pain sub-scales and changes in BML size*

From: Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults

 

BML size change at all 4 sites **

Total BML size change

 

Univariate (95% CI)

P

Multivariable (95% CI)†

P

Univariate (95% CI)

P

Multivariable (95% CI)†

P

No ROA

        

   Walking on a flat surface

0.15 (0.05, 0.26)

0.005

0.14 (0.06, 0.22)

0.001

0.30 (0.05, 0.54)

0.018

0.29 (0.11, 0.48)

0.002

   Going up and down stairs

0.16 (0.04, 0.28)

0.008

0.15 (0.05, 0.25)

0.003

0.33 (0.05, 0.60)

0.020

0.33 (0.09, 0.57)

0.006

   At night while in bed

0.13 (0.03, 0.23)

0.014

0.11 (0.04, 0.18)

0.002

0.22 (-0.01, 0.45)

0.066

0.21 (0.04, 0.38)

0.014

   Sitting or lying

0.06 (-0.03, 0.15)

0.172

0.07 (-0.01, 0.15)

0.073

0.11 (-0.10, 0.31)

0.314

0.14 (-0.04, 0.33)

0.130

   Standing upright

0.06 (-0.03, 0.15)

0.160

0.08 (-0.001, 0.16)

0.054

0.12 (-0.09, 0.33)

0.271

0.16 (-0.03, 0.35)

0.089

ROA present

        

   Walking on a flat surface

-0.02 (0.08, 0.05)

0.652

-0.02 (0.08, 0.05)

0.617

-0.02 (-0.15, 0.10)

0.686

-0.03 (-0.14, 0.09)

0.645

   Going up and down stairs

0.02 (-0.07, 0.12)

0.660

0.02 (-0.06, 0.11)

0.601

0.03 (-0.14, 0.20)

0.722

0.03 (-0.12, 0.19)

0.673

   At night while in bed

0.03 (-0.07, 0.14)

0.534

0.01 (-0.07, 0.09)

0.871

0.05 (-0.14, 0.25)

0.589

0.01 (-0.13, 0.16)

0.850

   Sitting or lying

0.01 (-0.08, 0.10)

0.863

-0.01 (-0.08, 0.06)

0.827

0.01 (-0.15, 0.17)

0.895

-0.01 (-0.14, 0.12)

0.847

   Standing upright

0.03 (-0.05, 0.12)

0.431

0.01 (-0.06, 0.07)

0.800

0.05 (-0.10, 0.21)

0.504

0.01 (-0.11, 0.14)

0.814

  1. *Values are the change in pain sub-scale score per one standard deviation change in BML size (mm2), stratified by ROA.
  2. β, beta coefficients; 95% CI, 95% confidence interval; BML, bone marrow lesion; ROA, radiographic osteoarthritis; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.
  3. **Medial tibial, medial femoral, lateral tibial, and lateral femoral.
  4. † Adjusted for age, sex, body mass index, leg strength, quality of life, and baseline pain sub-scale score depending on the model. Boldface denotes statistically significant result.
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Arthritis Research & Therapy

ISSN: 1478-6362

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