mPGES-1 is induced in human systemic sclerosis (SSc) fibroblasts and in response to bleomycin-induced skin sclerosis. (a, b) Western blot analysis showing upregulation in the expression of mPGES-1 in fibroblasts from the scars of SSc patients compared with fibroblasts from normal human skin (NF). Representative data from six separate cell lines per group are shown. (c) Western blot analysis showing induction of mPGES-1 in the skin of wild-type (WT) mice in response to 4-week treatment with bleomycin. Representative data from four separate animals per group are shown. mPGES-1, microsomal prostaglandin E2 sythnase-1.