Figure 2From: Tumor necrosis factor-alpha promotes survival in methotrexate-exposed macrophages by an NF-kappaB-dependent pathwayHuman (h) and murine (m) TNF-a confer comparable protection against apoptosis in RAW264.7 cells exposed to 10 mM MTX. Caspase-3 activity was measured after six hours with MTX, without TNF-a, or pre-treated with 10 ng/mL mTNF-a or hTNF-a for three hours. Shown are mean ± SEM of three independent experiments. * = P < 0.05.Back to article page