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Table 3 Comparison of test assay titers in patients with versus those without a distinct present clinical findinga

From: Anti-dsDNA-NcX ELISA: dsDNA-loaded nucleosomes improve diagnosis and monitoring of disease activity in systemic lupus erythematosus

   Pvalue
Disease feature Number of patients NcX dsDNA Nuc Farr CLIF
ACR criteria (ever), N = 207       
   Renal 101 0.01 0.03 0.01 ns ns
   Neurologic 23 0.01 0.03 0.01 0.04 ns
   Hematological 134 ns ns ns ns 0.04
mSLEDAI 2000 (current), N = 165       
   Casts 3 0.03 0.04 0.04 0.02 0.04
   Hematuria 13 <0.001 0.001 0.003 0.002 ns
   Proteinuria 16 0.04 ns ns ns ns
   Leukocyturia 3 0.04 0.02 ns ns ns
   Pleuritis 5 ns ns ns 0.01 ns
   Pericarditis 10 ns 0.02 ns ns ns
   Complement 84 0.003 0.005 0.004 0.01 0.03
   Fever 8 0.02 0.04 ns ns ns
   Thrombocytes 5 ns 0.04 ns ns 0.03
Laboratory (current), N = 165       
   Decreased lymphocytes 91 0.02 0.02 ns 0.03 ns
   Decreased monocytes 27 0.02 0.02 ns ns ns
   Decreased C-reactive protein 62 0.02 0.04 0.04 ns ns
   Decreased C3 83 0.004 0.001 0.01 0.004 ns
   Decreased C4 63 ns 0.04 ns ns ns
   Proteinuria >150 mg/d 39 0.01 ns 0.04 ns ns
  1. aComparison was performed using the Mann-Whitney U test. This table is reduced to statistically significant findings to increase readability. Significance with regard to any feature was always found for increased values of autoantibody assays. The number of patients with a positive finding (ACR and SLEDAI 2000) or an abnormal finding (local laboratory) of all patients is given. Current values refer to values on the date of blood withdrawal. NcX, anti-dsDNA-nucleosome-complexed enzyme-linked immunosorbent assay (ELISA); dsDNA, dsDNA, double-stranded DNA; Nuc, anti-dsDNA-nucleosome ELISA; Farr, radioimmunoassay; CLIF, Crithidia luciliae immunofluorescence assay; ACR, American College of Rheumatology; mSLEDAI 2000, modified Systemic Lupus Erythematosus Disease Activity Index 2000 [25]; C3, complement component C3; C4, complement component C4; ns, not significant.