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Table 1 Association of TLR7 SNPs with SLE in a Japanese populationa

From: TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study

      Allelic association Dominant model Recessive model
Study population Genotype, n(%) Risk allele, n(%) P OR (95% CI) P OR (95% CI) P OR (95% CI)
rs3853839 G/G G/C C/C G       
SLE 197(57.3) 125 (36.3) 22 (6.4) 519 (75.4) 0.017 1.36 (1.06 to 1.75) 0.030 1.87 (1.05 to 3.31) 0.072 1.34 (0.97 to 1.84)
Controls 137(50.0) 106 (38.7) 31 (11.3) 380 (69.3)       
rs179019 A/A C/A C/C A       
SLE 45 (13.1) 131 (38.1) 168 (48.8) 221 (32.1) 0.17 1.19 (0.93 to 1.52) 0.77 1.05 (0.76 to 1.44) 0.016b 2.02 (1.15 to 3.54)
Controls 19 (6.9) 118 (43.1) 137 (50.0) 156 (28.5)       
rs179010 T/T C/T C/C T       
SLE 61 (17.7) 156 (45.3) 127 (36.9) 278 (40.4) 0.062 1.25 (0.99 to 1.57) 0.36 1.16 (0.84 to 1.61) 0.018 1.75 (1.10 to 2.80)
Controls 30 (10.9) 133 (48.5) 111 (40.5) 193 (35.2)       
  1. aTLR7, Toll-like receptor 7 gene; SNP, single-nucleotide polymorphism; 95% CI, confidence interval; OR, odds ratio; SLE, systemic lupus erythematosus. Genotype and allele frequencies are shown in parentheses (%). Association was tested by χ2 analysis or Fisher's exact test using 2 × 2 contingency tables under the indicated models for rs3853839G, rs179019A and rs179010 T alleles. bFisher's exact test was used.