Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities

Table 3 Biochemical markers in rheumatoid arthritis clinical trials: selected studies evaluating MRI-based measures and biochemical markers

Reference	N	Design/study if named	Image modality	Markers evaluated	Results
[180]	84	Longitudinal analysis	MRI and X-ray	sCTX-I and uCTX-II sOPG, sYKL-40, sCOMP and sMMP-3	sCTX-I and uCTX-II were significant predictors of progressive joint destruction
[181]	377	Cross-sectional analysis	MRI	CTX-II	Correlation of uCTX-II with BME
[155]	98	Cross-sectional analysis	MRI	COMP, MMP-3, CRP	COMP was elevated in those with bone erosions
[182]	72	Longitudinal analysis	MRI	IL-6, VEGF, YKL-40, CRP and ESR	Only IL-6 correlated with disease progression

BME, bone marrow edema; COMP, cartilage oligomeric protein; CRP, C-reactive protein; CTX-I, C-terminal telopeptide of collagen type I; CTX-II, C-terminal telopeptide of collagen type II; ESR, erythrocyte sedimentation rate; MMP, matrix metalloproteinase; OPG, osteoprotegerin; s, serum; u, urinary; VEGF, vascular endothelial growth factor.

ISSN: 1478-6362