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Table 2 Number of cells stained positive in CIOA joints on Day 30

From: Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine

  Bone markers
Groups RANKL BMP2 TGF-β3 pSMAD2 DKK1
Healthy 5 ± 1 nd 109 ± 12 18 ± 3 75 ± 12
CIOA 65 ± 12 136 ± 21 145 ± 22 36 ± 6 32 ± 9
CIOA+Glu1 8 ± 1*** 102 ± 10* 112 ± 14* 12 ± 3*** 89 ± 13***
  1. Joint sections were obtained and stained as described in Figure 6. The number of positive cells was evaluated by a computerized imaging system. Data represent the mean of positive cells ± SD from two independent experiments involving five mice/group (10 joint sections/mice); nd, not detectable; Mann-Whitney U-test; *P < 0.05, ***P < 0.001 vs CIOA group.
  2. BMP, bone morphogenetic protein; CIOA, collagen-induced osteoarthritis; DKK1, Dickkopf-1; Glu, glucosamine hydrochloride; pSMAD-2, phosphorylated protein mothers against decapentaplegic homolog 2; RANKL, receptor activator of nuclear factor kappa B ligand; SD, standard deviation; TGF, transforming growth factor.