Perturbations in the impact of mutational activity on Vλ genes in systemic lupus erythematosus

Table 2 Ratio (R/S) of replacement mutations to silent mutations in regions of Vλ in a patient with SLE and in normal human subjects

	Patient with SLE		Normal subjects^*
Region of Vλ	Nonproductive rearrangements	Productive rearrangements	Nonproductive rearrangements	Productive rearrangements
FR1	1.0^b (4/4)	7.3^b (29/4)	0.0 (0)	1.8 (9/5)
CDR1	7.8 (47/6)	6.3^a (113/18)	3.0 (12/4)	3.9^a (55/14)
FR2	3.1 (49/16)	2.5 (95/38)	0.0^b (11/0)	1.8^b (51/29)
CDR2	8.2 (41/5)	10.9 (76/7)	10.0 (10/1)	4.8 (48/10)
FR3	2.9 (112/39)	3.1 (185/59)	4.0 (12/3)	2.4 (66/28)
CDR3	8.7 (52/6)	8.0^a (96/12)	3.0 (15/5)	3.7^a (81/22)
FRs	2.8 (165/59)	3.1^a (309/101)	7.7^b (23/3)	2.0^a,b (126/62)
CDRs	8.2 (140/17)	7.7^a (285/37)	3.7 (37/10)	4.0^a (184/46)
Total	4.0 (305/76)	4.3^a (594/138)	4.6 (60/13)	2.9^a (310/108)

^*The data for normal subjects have been published elsewhere [23]. ^aSignificant difference between ratio in SLE patient and normal subjects; P < 0.05 (Χ² test). ^bSignificant difference between ratio in nonproductive and productive rearrangements; P < 0.05 (Χ² test). CDR = complementarity-determining region; FR = framework region.

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