Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects

Table 3 Gene ontology analysis

GO category	GO ontology	GO term	LS permutation P-value
GO:0002820	BP	Negative regulation of adaptive immune response	0.00001
GO:0033077	BP	T cell differentiation in the thymus	0.00001
GO:0043383	BP	Negative T cell selection	0.00001
GO:0045061	BP	Thymic T cell selection	0.00001

The dataset showed two key immune-associated pathways to be altered, "negative regulation of adaptive immune response" and several ontologies affecting "thymic T cell selection" both with P-values <0.005.

ISSN: 1478-6362