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Table 2 IL-1-responsive genes in chondrocytic cells

From: Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta

Fold Fold   
Gene description Genbank#
Panel A:   Transcription Factors/RNA-binding Proteins  
18.0   I-rel (RELB) M83221
17.0   nuclear factor NF-kappa-B p100 subunit; nuclear factor NF-kappa-B p52 subunit; H2TF1; oncogene lyt-10 X61498
15.7   interferon regulatory factor 1 (IRF1) X14454
13.7   major histocompatibility complex enhancer-binding protein MAD3 M69043
8.1   nuclear factor kappa-B DNA binding subunit (NF-kappaB; NFKB) M58603
5.5   octamer-binding transcription factor 2 (oct-2; OTF2); lymphoid-restricted immunoglobulin octamer M36542
   binding protein NF-A2; POU2F2  
4.7   IkappaB epsilon (IKBE) U91616
3.0   c-rel proto-oncogene protein X75042
2.8   fos-related antigen (FRA1) X16707
2.4   STAT-induced STAT inhibitor 3 AB004904
2.4   erythroblastosis virus oncogene homolog 1 (ETS-1); p54 J04101
2.3   jun-B M29039
2.2   ELAV-like neuronal protein 1 (HEL-N1) + HEL-N2 U12431 +
    U29943
2.0   myb proto-oncogene; c-myb M15024
2.0   NF-kappaB transcription factor p65 subunit; RELA; NFKB3 L19067
2.0   transcription factor erf-1; AP2 gamma transcription factor U85658
2.0   early growth response alpha (EGR alpha) S81439
  6.0 homeobox protein HOX-D3; HOX-4A D11117
  2.0 retinoblastoma-like protein 2 (RBL2; RB2); 130-kDa retinoblastoma-associated protein X74594
  2.0 mothers against dpp homolog 4 (SMAD4); MADR4; pancreatic carcinoma gene 4 (DPC4) U44378
Panel B:   Cytokines/Growth Factors/Receptors  
21   leukemia inhibitory factor precursor (LIF); differentiation-stimulating factor (D factor); melanoma-derived X13967;
   LPL inhibitor (MLPLI); HILDA M63420
8.7   interleukin-11 (IL-11); adipogenesis inhibitory factor (AGIF) M57765
6.1   interferon-gamma (IFN-gamma) receptor beta subunit precursor; IFN-gamma accessory factor 1 (AF1); U05875
   IFN-gamma transducer 1 (IFNGT1)  
6.1   interleukin-6 precursor (IL-6); B-cell stimulatory factor 2 (BSF2); interferon beta-2 (IFNB2); X04602;
   hybridoma growth factor M14584
5.9   heparin-binding EGF-like growth factor (HBEGF); diphtheria toxin receptor (DTR) M60278
5.0   interferon gamma-induced protein precursor (gamma-IP10) X02530
4.3   putative serine/threonine protein kinase PRK U56998
4.3   CD40 receptor-associated factor 1 (CRAF1) U21092
3.6   platelet-derived growth factor A subunit precursor (PDGFA; PDGF1) X06374
3.0   bone morphogenetic protein 3B precursor (BMP3B); growth differentiation factor 10 (GDF10); D49493
   bone inducing protein (BIP)  
2.5   CD40 ligand (CD40-L); tumor necrosis factor (TNF)-related activation protein (TRAP); T-cell antigen GP39 L07414
2.1   interleukin-12 beta subunit precursor (IL-12B); cytotoxic lymphocyte maturation factor 40-kDa subunit M65290
   (CLMF p40); NK cell stimulatory factor subunit 2 (NKSF2)  
2.1   glial growth factor 2 precursor (GGFHPP2); neuregulin; heregulin-beta3 + neu differentiation factor + L12260;
   heregulin-alpha L12261 +
    U02326 +
    M94165
2.0   platelet-derived growth factor B subunit precursor (PDGFB; PDGF2); bacaplermin; c-sis X02811;
    X02744;
    M12783;
    M16288
  7.8 bone morphogenetic protein 4 (BMP4) + bone morphogenetic protein 2B (BMP2B) D30751 +
    M22490
  2.3 platelet-derived growth factor receptor alpha subunit (PDGFRA); CD140A antigen M21574
  2.3 platelet-derived growth factor receptor beta subunit (PDGFRB); CD140B antigen M21616
Panel C:   Proteases/Matrix Proteins  
3.0   matrix metalloproteinase 13 (MMP-13); collagenase 3 precursor X75308
2.3   matrix metalloproteinase 7 (MMP-7); matrilysin X07819
2.1   matrix metalloproteinase 12 (MMP-12); metalloelastase L23808
2.1   collagen 6 alpha 2 subunit (COL6A2) M34570
2.1   tissue-type plasminogen activator precursor (T-plasminogen activator; TPA) M15518;
    X07393;
    M18182
2.0   urokinase-type plasminogen activator receptor GPI-anchored form precursor (U-PAR); monocyte activation U08839;
   antigen MO3; CD87 antigen M83246;
    X51675
  3.0 chymotrypsin-like protease CTRL-1 precursor X71874
  2.0 cysteine protease D55696
   Adhesion Molecules  
3.5   ninjurin-1 U72661
3.0   desmocollin 3A/3B precursor (DSC3) + desmocollin 4 (DSC4) X83929 +
    D17427
2.8   tenascin precursor (TN); hexabrachion (HXB); cytotactin; neuronectin; GMEM; miotendinous antigen; X78565;
   glioma-associated extracellular matrix antigen M55618
2.2   alpha-catenin related protein (CAPR); alpha 2 catenin (CTNNA2); alpha N-catenin M94151
  4.0 opioid-binding protein/cell adhesion molecule precursor (OBCAM); opioid-binding cell adhesion L34774
   molecule (OPCML)  
  3.0 integrin beta 4 (ITGB4); CD104 antigen X53587;
    X52186;
    X51841
  2.2 integrin alpha 1 (ITGA1); laminin & collagen receptor; VLA1; CD49A antigen X68742
Panel D:   Signaling Intermediates  
7.0   rho6 protein Y07923
2.9   Gem; induced immediate early protein; ras family member (ras-like protein KIR) U10550
2.6   regulator of G protein signaling 3 (RGS3; RGP3) U27655
2.5   dual-specificity protein phosphatase 8; HVH5 U27193
2.3   death receptor 5 (DR5); cytotoxic TRAIL receptor 2 (TRICK2A) AF016268
2.1   protein kinase DYRK3 Y12735
2.1   jagged 1 (HJ1) AF028593
  6.0 C-fgr proto-oncogene (p55-FGR); SRC2 M19722
  4.0 rho7 protein X95456
  3.0 GTP-binding protein ras associated with diabetes (RAD1) L24564
  2.7 rho-associated coiled-coil containing protein kinase p160ROCK U43195
  2.5 frizzled L37882
  2.3 cyclin-dependent kinase 4 inhibitor D (CDKN2D); p19-INK4D U40343;
    U20498
  2.3 phosphotyrosyl phosphatase activator X73478
  2.3 protein kinase C-binding protein RACK7 U48251
  2.2 A-raf proto-oncogene serine/threonine-protein kinase; PKS2 L24038
  2.2 STE20-like kinase; MST2 U26424
  2.1 phosphorylase B kinase beta regulatory subunit X84908
  2.0 protein phosphatase 2A B56-alpha L42373
   Tumor Suppressors  
11.0   melanoma differentiation-associated protein 7 precursor (MDA7) U16261
  2.3 tumor suppressor protein DCC precursor; colorectal cancer suppressor X76132