Table 2 IL-1-responsive genes in chondrocytic cells

Transcription Factors/RNA-binding Proteins

I-rel (RELB)

M83221

nuclear factor NF-kappa-B p100 subunit; nuclear factor NF-kappa-B p52 subunit; H2TF1; oncogene lyt-10

X61498

interferon regulatory factor 1 (IRF1)

X14454

major histocompatibility complex enhancer-binding protein MAD3

M69043

nuclear factor kappa-B DNA binding subunit (NF-kappaB; NFKB)

M58603

octamer-binding transcription factor 2 (oct-2; OTF2); lymphoid-restricted immunoglobulin octamer

M36542

binding protein NF-A2; POU2F2

IkappaB epsilon (IKBE)

U91616

c-rel proto-oncogene protein

X75042

fos-related antigen (FRA1)

X16707

STAT-induced STAT inhibitor 3

AB004904

erythroblastosis virus oncogene homolog 1 (ETS-1); p54

J04101

jun-B

M29039

ELAV-like neuronal protein 1 (HEL-N1) + HEL-N2

U12431 +

U29943

myb proto-oncogene; c-myb

M15024

NF-kappaB transcription factor p65 subunit; RELA; NFKB3

L19067

transcription factor erf-1; AP2 gamma transcription factor

U85658

early growth response alpha (EGR alpha)

S81439

homeobox protein HOX-D3; HOX-4A

D11117

retinoblastoma-like protein 2 (RBL2; RB2); 130-kDa retinoblastoma-associated protein

X74594

mothers against dpp homolog 4 (SMAD4); MADR4; pancreatic carcinoma gene 4 (DPC4)

U44378

Cytokines/Growth Factors/Receptors

leukemia inhibitory factor precursor (LIF); differentiation-stimulating factor (D factor); melanoma-derived

X13967;

LPL inhibitor (MLPLI); HILDA

M63420

interleukin-11 (IL-11); adipogenesis inhibitory factor (AGIF)

M57765

interferon-gamma (IFN-gamma) receptor beta subunit precursor; IFN-gamma accessory factor 1 (AF1);

U05875

IFN-gamma transducer 1 (IFNGT1)

interleukin-6 precursor (IL-6); B-cell stimulatory factor 2 (BSF2); interferon beta-2 (IFNB2);

X04602;

hybridoma growth factor

M14584

heparin-binding EGF-like growth factor (HBEGF); diphtheria toxin receptor (DTR)

M60278

interferon gamma-induced protein precursor (gamma-IP10)

X02530

putative serine/threonine protein kinase PRK

U56998

CD40 receptor-associated factor 1 (CRAF1)

U21092

platelet-derived growth factor A subunit precursor (PDGFA; PDGF1)

X06374

bone morphogenetic protein 3B precursor (BMP3B); growth differentiation factor 10 (GDF10);

D49493

bone inducing protein (BIP)

CD40 ligand (CD40-L); tumor necrosis factor (TNF)-related activation protein (TRAP); T-cell antigen GP39

L07414

interleukin-12 beta subunit precursor (IL-12B); cytotoxic lymphocyte maturation factor 40-kDa subunit

M65290

(CLMF p40); NK cell stimulatory factor subunit 2 (NKSF2)

glial growth factor 2 precursor (GGFHPP2); neuregulin; heregulin-beta3 + neu differentiation factor +

L12260;

heregulin-alpha

L12261 +

U02326 +

M94165

platelet-derived growth factor B subunit precursor (PDGFB; PDGF2); bacaplermin; c-sis

X02811;

X02744;

M12783;

M16288

bone morphogenetic protein 4 (BMP4) + bone morphogenetic protein 2B (BMP2B)

D30751 +

M22490

platelet-derived growth factor receptor alpha subunit (PDGFRA); CD140A antigen

M21574

platelet-derived growth factor receptor beta subunit (PDGFRB); CD140B antigen

M21616

Proteases/Matrix Proteins

matrix metalloproteinase 13 (MMP-13); collagenase 3 precursor

X75308

matrix metalloproteinase 7 (MMP-7); matrilysin

X07819

matrix metalloproteinase 12 (MMP-12); metalloelastase

L23808

collagen 6 alpha 2 subunit (COL6A2)

M34570

tissue-type plasminogen activator precursor (T-plasminogen activator; TPA)

M15518;

X07393;

M18182

urokinase-type plasminogen activator receptor GPI-anchored form precursor (U-PAR); monocyte activation

U08839;

antigen MO3; CD87 antigen

M83246;

X51675

chymotrypsin-like protease CTRL-1 precursor

X71874

cysteine protease

D55696

Adhesion Molecules

ninjurin-1

U72661

desmocollin 3A/3B precursor (DSC3) + desmocollin 4 (DSC4)

X83929 +

D17427

tenascin precursor (TN); hexabrachion (HXB); cytotactin; neuronectin; GMEM; miotendinous antigen;

X78565;

glioma-associated extracellular matrix antigen

M55618

alpha-catenin related protein (CAPR); alpha 2 catenin (CTNNA2); alpha N-catenin

M94151

opioid-binding protein/cell adhesion molecule precursor (OBCAM); opioid-binding cell adhesion

L34774

molecule (OPCML)

integrin beta 4 (ITGB4); CD104 antigen

X53587;

X52186;

X51841

integrin alpha 1 (ITGA1); laminin & collagen receptor; VLA1; CD49A antigen

X68742

Signaling Intermediates

rho6 protein

Y07923

Gem; induced immediate early protein; ras family member (ras-like protein KIR)

U10550

regulator of G protein signaling 3 (RGS3; RGP3)

U27655

dual-specificity protein phosphatase 8; HVH5

U27193

death receptor 5 (DR5); cytotoxic TRAIL receptor 2 (TRICK2A)

AF016268

protein kinase DYRK3

Y12735

jagged 1 (HJ1)

AF028593

C-fgr proto-oncogene (p55-FGR); SRC2

M19722

rho7 protein

X95456

GTP-binding protein ras associated with diabetes (RAD1)

L24564

rho-associated coiled-coil containing protein kinase p160ROCK

U43195

frizzled

L37882

cyclin-dependent kinase 4 inhibitor D (CDKN2D); p19-INK4D

U40343;

U20498

phosphotyrosyl phosphatase activator

X73478

protein kinase C-binding protein RACK7

U48251

A-raf proto-oncogene serine/threonine-protein kinase; PKS2

L24038

STE20-like kinase; MST2

U26424

phosphorylase B kinase beta regulatory subunit

X84908

protein phosphatase 2A B56-alpha

L42373

Tumor Suppressors

melanoma differentiation-associated protein 7 precursor (MDA7)

U16261

tumor suppressor protein DCC precursor; colorectal cancer suppressor

X76132