(NZB/NZW)F1
|
SG and LG infl.
|
SLE-like disease
|
[19]
|
MRL
|
SG and LG infl.
|
SLE-like disease
|
[29]
|
lpr
|
↑ SG and LG infl.
|
lpr exacerbates the MRL disease phenotype
|
[30]
|
NFS/sld
|
None
|
Aberrant proteolysis of α-fodrin
|
[33]
|
3d-Tx
|
SG and LG infl.
|
Inflammatory lesions in multiple organs
|
[34]
|
IQI/Jic
|
SG and LG infl.
|
Inflammatory lesions in multiple organs
|
[37]
|
NOD
|
SG and LG infl., ↓ SG and LG function
|
T1D, multiple immune system-related alterations
|
[12]
|
H2b
|
Similar to original NOD strain
|
No T1D
|
[42]
|
C57BL/6
|
May develop SG infl. at an old age
|
Widely used recipient strain
| |
NOD-Aec1Aec2
|
SG and LG infl., ↓ SG and LG function
|
Increased applicability compared with NOD mice
|
[41]
|
Il2-/-
|
SG and LG infl., ↓ SG function
|
Generalized lymphoproliferative disease
|
[91]
|
Il2Rα-/-
|
SG and LG infl., ↓ SG function
|
Generalized lymphoproliferative disease
|
[91]
|
Foxp3-/-
|
None
|
More susceptible to SS-like disease
|
[94]
|
Il10 Tg
|
SG and LG infl., ↓ SG and LG function
|
↑ apoptosis in the SG
|
[95]
|
Il14α Tg
|
SG infl., ↓ SG function
|
High incidence of CD5+ lymphoma, nephritis
|
[101]
|
Baff Tg
|
SG and LG infl., ↓ SG function
|
MZ B-cell dominated infl., SLE-like disease
|
[106]
|
Tgfβ1-/-
|
SG and LG infl., ↓ SG function
|
Poor viability, mixed inflammatory cell response
|
[112]
|
Tgfβ1 Tg
|
↓ SG function
|
Impaired SG architecture, SG tissue fibrosis
|
[113]
|
Thbs1-/-
|
LG infl., anti-Ro and anti-La
|
Detailed assessment of the eye component
|
[116]
|
Ar
-/-
|
SG infl.
|
Estrogen-dependent disease
|
[119]
|
RbAp48 Tg
|
SG and LG infl., ↓ SG function, anti-Ro and anti-La
|
Assessment of the inflammatory milieu in the SG
|
[122]
|
Id3-/-
|
SG and LG infl., ↓ SG function, anti-Ro and anti-La
|
Exocrine gland dysfunction precedes SG and LG infl.
|
[125]
|
Id3-/-;LckCre
|
SG and LG infl., ↓ SG function, anti-Ro and anti-La
|
T-cell lineage specific deletion of Id3
|
[126]
|
r1ΔT/r2n
|
SG and LG infl., anti-Ro
|
↓ Tregs, inflammatory lesions in multiple organs
|
[130]
|
IκBαM/M
|
SG and LG infl., anti-Ro and anti-La
|
Defective feedback regulation of NF-κB
|
[133]
|
C57BL/10
|
May develop SG infl. at an old age
|
C57BL/6 and C57BL/10 diverged prior to 1937
| |
NOD-Nss1/Idd5
|
SG infl.
|
SG function has not been assessed
|
[82]
|
SJL
|
SG and LG infl., anti-Ro and anti-La
|
Susceptible to multiple autoimmune diseases
|
[98]
|
Il12 Tg
|
↑ SG and LG infl., ↓ SG function, ↑ anti-Ro and anti-La
|
IL-12 exacerbates the SJL disease phenotype
|
[98]
|
BALB/c
|
None
|
Often used as control strain
| |
Act1-/-
|
SG and LG infl., anti-Ro and anti-La
|
MZ B-cell dominated infl., SLE-like disease
|
[115]
|