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Figure 2 | Arthritis Research & Therapy

Figure 2

From: CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes

Figure 2

OSM stimulus IL-6 mRNA expression in RA-FLS, OSM stimulates IL-6 synthesis in RA-FLS. (a) RA-FLS were stimulated with 20 ng/ml of recombinant OSM for various times as indicated. IL-6 and GAPDH mRNA expression was determined by real-time PCR method. The data were expressed as the mean ± SD of three independent experiments. *P < 0.01 compared to untreated RA-FLS. (b) RA-FLS were stimulated with various concentrations of recombinant OSM as indicated for 24 hours. IL-6 protein in the conditioned media was determined by ELISA. The data were expressed as the mean ± SD of three independent experiments. *P < 0.01 compared to untreated RA-FLS.

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