Figure 8From: CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytesCP690,550 suppresses IL6-induced STAT3 activation in RA-FLS. Quiescent RA-FLS were stimulated with IL-6 (100 ng/ml) plus sIL-6R (100 ng/ml) for 20 minutes. Phosphorylation of STAT3 were determined by Western blotting using phospho-specific or pan antibodies against STAT3. Three experiments were performed using different RA-FLS and a representative result is shown.Back to article page