The effects of trichostatin A on SKG mice. Zymosan A was administered to SKG mice. Dimethyl sulfoxide or trichostatin A was injected subcutaneously daily for 28 days (Day 14 through Day 42). The clinical arthritis scores were evaluated and the results are expressed as the mean ± SE (DMSO group: n = 5, TSA group: n = 5). * P < 0.05.