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Table 2 Association of pain withdrawal threshold with the immunoreactivity results given as gamma values

From: Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model

  Pain withdrawal threshold
  1D 3D 3D6d
HIF-1α -0.378a -0.848a -0.869a
iNOS -0.280b -0.782a -0.765a
MMP3 -0.420a -0.823a -0.856a
  1. Correlations were analyzed by Pearson correlation coefficients. aP < 0.01; bP < 0.05.
  2. 1D, one dose; 3D, three doses; 3D6d, follow-up at the 6th day after three doses; HIF-1α, hypoxia-inducible factor-1-alpha; iNOS, inducible nitric oxide synthase; MMP3, matrix metalloproteinase-3.