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Table 2 Association of pain withdrawal threshold with the immunoreactivity results given as gamma values

From: Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model

 

Pain withdrawal threshold

 

1D

3D

3D6d

HIF-1α

-0.378a

-0.848a

-0.869a

iNOS

-0.280b

-0.782a

-0.765a

MMP3

-0.420a

-0.823a

-0.856a

  1. Correlations were analyzed by Pearson correlation coefficients. aP < 0.01; bP < 0.05.
  2. 1D, one dose; 3D, three doses; 3D6d, follow-up at the 6th day after three doses; HIF-1α, hypoxia-inducible factor-1-alpha; iNOS, inducible nitric oxide synthase; MMP3, matrix metalloproteinase-3.