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Table 2 Histomorphometry data eight weeks after anterior cruciate ligament transection in dogs

From: Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model

  Calcified cartilage surface (10 -2 mm 2 ) Subchondral bone surface (10 -2 mm 2 ) Trabecular thickness (10 -2 mm) Trabecular separation (10 -3 mm)
Placebo-control 16.9 (3.9) 75.1 (9.3) 8.9 (2.3) 86.0 (52.6)
Tiludronate 19.8 (2.3) 86.2 (5.1)* 10.3 (2.0) 45.5 (15.1)*
  1. Tiludronate was injected subcutaneously at 2 mg/kg, starting immediately on the day of ACL transection and repeated every two weeks for an eight-week follow-up. Osteoarthritic placebo-treated dogs received mannitol injection in a similar fashion.
  2. Data presented are mean (SD). * Statistically significant (P < 0.01) compared to placebo-control.