Figure 7
From: Defective response of CD4+T cells to retinoic acid and TGFβ in systemic lupus erythematosus
PBX1-D expression affects FOXP3 and CD25 induction by retinoic acid and (transforming growth factor beta). Combined CD4+ T cells from systemic lupus erythematosus patients (SLE) and healthy controls (HCs) were partitioned according to their expression of the PBX1-A (white), PBX1-D (black), co-expression of both PBX1-A and PBX1-D (A/D, light hatched) or either PBX1-D or PBX1-A/D (heavy hatched) isoforms. The expansion of CD25- regulatory T cells (Tregs) (a), Tregs (b) and CD25+ FOXP3- CD4+ T cells (c) is shown by retinoic acid (RA) alone (left panels), transforming growth factor beta (TGFβ) alone (middle panels), or the combination of the two (right panels).