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Table 1 Five anti-RNAP III positive cases that were not classified as SSc at their initial visit

From: Atypical clinical presentation of a subset of patients with anti-RNA polymerase III - non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining

 

1

2

3

4

5

 

Initial

f/u

Initial

f/u

   

Diagnosis

Vasculitis?

SSc

Poly

-arthritis

SSc

Sine SSc?

ILD

Sjögren's syndrome

Race/gender

WF

Mixed F

WF

WF

WF

Anti-RNAP III

ELISA (u)

16

NA

99

127

8

15

to 47

42

Proximal scleroderma

N

Y

< 10 mo

N

Y

3 mo

N

N

N

Sclerodactyly

N

Y

< 10 mo

N

Y

2 mo

N

N

N

Pitting scar

N

N

N

N

N

N

N

ILD

N

N

N

N

N

Y

N

Raynaud's phenomenon

N

?

N

Y

6 mo

Y

For 10 y

N

N

Other

 

Renal crisis

10 mo

 

Flex.cont

PH

ARF (TMA), DCM

  
  1. ARF, acute renal failure; DCM, dilated cardiomyopathy; W, white; F, female; Flex cont, flexion contracture; f/u, follow up; ILD, interstitial lung disease; N, no; NA, not available; PH, pulmonary hypertension; SSc, systemic sclerosis, scleroderma; TMA, thrombotic microangiopathy; Y, yes