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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Increasing levels of circulating Th17 cells and interleukin-17 in rheumatoid arthritis patients with an inadequate response to anti-TNF-α therapy

Figure 2

The change in circulating levels of Th17-cells and Th17-related cytokines in EULAR responders and non-responders. The changes in (A) the frequencies of circulating Th17-cells (T helper-type 17 cells) and serum levels of (B) interleukin (IL)-17, (C) IL-6, (D) IL-21, (E) IL-23, and (F) tumor necrosis factor (TNF)-α in 36 responders and 12 non-responders to anti-TNF-α therapy according to European League Against Rheumatism (EULAR) response criteria. Bars represent the mean value and SEM. *P < 0.05, **P < 0.005, ***P < 0.001, versus before starting anti-TNF-α therapy, determined by the Wilcoxon signed rank test.#P < 0.01, non-responders versus responders.

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