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Table 1 Animal models of arthritis

From: Characterization of a novel and spontaneous mouse model of inflammatory arthritis

Model Abbreviation Species Feature
Induced models    
   Non-specific immune stimuli    
Adjuvant-induced arthritis AA Lewis rat Autoimmune
Oil-induced arthritis OIA DA rat Autoimmune
Pristane-induced arthritis PIA DA ra Autoimmune
   Cartilage directed autoimmunity    
Collagen-induced arthritis CIA DBA mouse CII AI
Proteoglycan-induced arthritis PGIA Balb/c mouse PG AI
   Infectious agents/exogenous triggers    
Streptococcal cell wall arthritis SCW-A Lewis rat Persistent bacteria AI
Flare SCW-F Mouse Th17
Antigen-induced arthritis AIA Rabbit, mouse Persistent antigen
Flare AIA-F Mouse Th17
Transgenic spontaneous models    
   HTLV-induced arthritis HTLV Mouse Viral tax antigen
   KRN arthritis KRN K/BxN mouse GPI AI
   SKG arthritis SKG Mouse ZAP-70 T cell defect
   GP130 arthritis GP130 Mouse STAT3, T cell defect
   TNF transgenic arthritis TNFtg Mouse TNF overexpression
   IL-1ra transgenic arthritis IL-1ra-/- Balb/c mouse Autoimmune T cells
   IL-1 transgenic arthritis IL-1tg Mouse IL-1 overexpression
Immune complex models    
   Collagen type II CAIA DBA mouse Mouse CII antibody
   KRN serum GPI Balb/c mouse Mouse GPI antibody
   Poly-L-lysine-lysozyme PLL-L DBA mouse Cationic antigen
New animal model    
   Spontaneous    
Inherited inflamed joints strain IIJ Arthritic male mouse crossed with SJL/J females Autoimmune arthritis (for understanding the female bias)
  1. AI, autoimmunity; CII, collagen type II; GPI, glucose-6-phosphate isomerase; HTLV, human T-lymphotropic virus; IL, interleukin; KRN, C57Bl/6 mice carrying the KRN transgene heterozygously; PG, proteoglycan; SKG, SKG strain, derived from closed breeding colony of BALB/c mice, spontaneously develops chronic arthritis; TNF, tumor necrosis factor.